Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy

Main Article Content

Şeyda Belli
Halit Demir
Ayşegül Kırankaya

Abstract

Objective: In this study, we investigated the glutathione peroxidase enzyme activity changes in patients with oral cavity malignancies.


Material and Methods: Twenty-five patients with oral cavity malignancy and 24 healthy individuals were included in the study. There was no statistically significant difference between the groups in terms of age, gender and smoking-alcohol consumption habits.


Results: Glutathione peroxidase activity was found to be significantly lower in the blood of patients with oral cavity malignancies than the control group ( 2,238±0,039,  p: 0,0001).


Conclusion: The level of glutathione peroxidase in the blood can be used as an important biomarker for the prognosis and to guide to the treatment approaches for the patients with oral cavity malignancy.

Downloads

Download data is not yet available.

Article Details

How to Cite
Belli Şeyda, DemirH., & KırankayaA. (2019). Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy. Medical Science and Discovery, 6(4), 84-87. Retrieved from http://medscidiscovery.com/index.php/msd/article/view/225
Section
Research Article

References

1. Malik UU, Siddiqui IA, Hashim Z, Zarina S. Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma. Clin Chim Acta. 2014 Mar 20;430:38-42. Doi: 10.1016/j.cca.2013.12.033
2. Özkaya Toraman K, Altun M. Oral Kavite Kanseri Tedavisine Güncel Bakış. Ünür M, editör. Ağız Kanserlerinin Tanı, Tedavi ve Prognozu. 1. Baskı. Ankara: Türkiye Klinikleri; 2019. p.24-33.
3. Krüger M, Pabst AM, Al-Nawas B, Horke S, Moergel M. Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis. J Cancer Res Clin Oncol. 2015 Oct;141(10):1757-66. Doi: 10.1007/s00432-015-1941-2
4. Prabhu K, Bhat GP. Serum total glutathione-s-transferase levels in oral cancer. J Cancer Res Ther. 2007 Jul-Sep;3(3):167-8. PMID: 18079581
5. Fu TY, Hou YY, Chu ST, Liu CF, Huang CH, Chen HC, Hsiao M, Lu PJ, Wang JS, Ger LP. Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas. Head Neck. 2011 Nov;33(11):1606-15. doi: 10.1002/hed.21653. PMID:21990225
6. Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D.Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer. Otolaryngol Pol. 2016 Nov 20;70(6):20-25. doi: 10.5604/01.3001.0009.3735. PMID: 28485283
7. Lee JR, Roh JL, Lee SM, Park Y, Cho KJ, Choi SH, Nam SY, Kim SY. Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2017 Nov;143(11):2257-2265. doi: 10.1007/s00432-017-2466-7. Epub 2017 Jun 26. PMID: 28653098
8. Gurudath S, Ganapathy K, D S, Pai A, Ballal S, Ml A. Estimation of superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia and oral cancer--a comparative study. Asian Pac J Cancer Prev. 2012;13(9):4409-12. Doi: 10.7314/APJCP.2012.13.9.4409 PMID: 23167351
9. Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell. 2006 Sep;10(3):241-52 DOI: 10.1016/j.ccr.2006.08.009. PMID: 16959615
10. Banerjee S, Mukherjee S, Mitra S, Singhal P. Altered expression of mitochondrial antioxidants in oral squamous cell carcinoma. J Oral Sci. 2017;59(3):439-446. doi: 10.2334/josnusd.16-0655.
11. Fu TY, Tsai MH, Wang JS, Ger LP. Antioxidant enzymes in oral verrucous carcinoma. J Oral Pathol Med. 2017 Jan;46(1):46-49. doi: 10.1111/jop.12460. Epub 2016 Jun 1.PMID: 27245640
12. Balasenthil S, Saroja M, Ramachandran CR, Nagini S.Of humans and hamsters: comparative analysis of lipid peroxidation, glutathione, and glutathione-dependent enzymes during oral carcinogenesis. Br J Oral Maxillofac Surg. 2000 Aug;38(4):267-70. PMID: 10922148
13. Sabitha KE, Shyamaladevi CS. Oxidant and antioxidant activity changes in patients with oral cancer and treated with radiotherapy. Oral Oncol. 1999 May;35(3):273-7. PMID: 10621847