Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy

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Refah Sayin
Mehmet Nuri Aydin
Mehmet Hamamci


Metronidazole is a potent drug used against some protozoa like Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis and Balantidium coli, and anaerobic bacteria. It is used for the treatment of alcoholism, Crohn’s disease, exophthalmos, rheumatoid arthritis, rosea and acne as well. It is a well-tolerated drug with some kinds of side effects like abdominal pain, headache, nausea and metallic taste. Rarely but severely, pseudomembranous colitis, epileptic seizure, encephalopathy and peripheral neuropathy might be seen. These side effects are generally self-limited. Drug administration should be stopped immediately in case of these side effects’ existence. In this article, we presented a case which used metronidazole for hepatic ameobiasis in a time period of 4 and a half months, and developed peripheral neuropathy.


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Sayin, R. ., Aydin, M. N., & Hamamci, M. . (2016). Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy. Medical Science and Discovery, 3(5), 239–241. Retrieved from
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