Developing Hemophagocytic Syndrome during the transformation of Chronic Lymphocytic Leukemia: Case reports of t(7;14), t(14;19) and deletion of 17 p

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Tarik Onur Tiryaki
Sezen Genc
Gulcin Bagatir Ozan
Kivanc Cefle
Gulcin Yegen
Oner Dogan
Meliha Nalcaci
Şükrü Palandüz


Objective: Chronic lymphocytic Leukemia (CLL) is the most common form of leukemia in adults. Clinical findings may broad range vary. Detecting some deletions using the FISH method may help us to foresee the progression of the disease and to choose a better treatment method in healing the patient.

Case: In this case report, we will present you a CLL patient with t(7;14), t(14;19) and  17p deletions, which are known for bad prognosis, developing autoimmune hemolytic anemia which is refractor to the treatment. This patient unfortunately died due to a clinical form of hemophagocytic syndrome including prolymphocytic transformation.  


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Tiryaki, T. O. ., Genc, S. ., Ozan, G. B. ., Cefle, K. ., Yegen, G., Dogan, O. ., Nalcaci, M. ., & Palandüz, Şükrü. (2018). Developing Hemophagocytic Syndrome during the transformation of Chronic Lymphocytic Leukemia: Case reports of t(7;14), t(14;19) and deletion of 17 p. Medical Science and Discovery, 5(5), 188–191. Retrieved from
Case Reports


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