Effect of serum vitamin D levels on weight loss in obese patients doing aerobic exercises: A retrospective study
Article Sidebar
Main Article Content
Abstract
Objective: This study evaluates the effect of serum vitamin D (Vit D) levels on weight loss in obese patients during an aerobic exercise program.
Material and Methods: The study included 88 participants with body mass index (BMI) ≥25 kg/m2. A serum level of 25(OH)D3 >30 ng/ml was accepted as normal, 20–29 ng/ml as insufficient and <20 ng/ml as deficient. The obese patients were classified into three groups based on a serum level of 25(OH)D3. All participants enrolled on an eight-week aerobic exercise program. The BMI, body fat percentage (BF%) and body fat mass (BFM) of the participants were measured before and after aerobic exercise.
Results: No statistically significant differences were identified between the groups in the first and last measured BMI, BF% and BFM values (p>0.05). The differences between the first and last measured weights, BMI, BF% and BFM were statistically significant within the groups (p<0.05).
Conclusion: Aerobic exercise can lead to weight loss in obese patients, although the level of serum Vit D has no effect on weight loss in obese patients engaged in aerobic exercise.
Downloads
Article Details
Accepted 2020-01-17
Published 2020-01-23
References
Aydın E, Bulut H. Nursing care in bariatric surgery. TAF Preventive Medicine Bulletin. 2014; 13: 77-82.
Pi-Sunyer X. The medical risks of obesity. Postgraduate Medicine. 2009; 12: 6-11
Reid I.R, Bolland M.J, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014;383:146–155.
Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer H.F, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr. Rev. 2008;29:726–776.
Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080S 6S.
Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012;33:456-92.
Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care 2002;9:2244–6.
Need AG, O’Loughlin PD, Horowitz M, Nordin BE. Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women. Clin Endocrinol (Oxf) 2005;62:738-41.
McGill AT, Stewart JM, Lithander FE, Strik CM, Poppitt SD. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J 2008;7:4
Moy FM, Bulgiba A. High prevalence of Vitamin D insufficiency and its association with obesity and metabolic syndrome among malay adults in Kuala Lumpur, Malaysia. BMC Public Health 2011;11:735
Perna. Is Vitamin D Supplementation Useful for Weight Loss Programs? A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicina (Kaunas). 2019;12:55-7
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon MC, Hanley DA, Heaney RP et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96:1911-30
Bringhurst FR, Demay MB, Krane SM, Kronenberg HM. Bone and Mineral Metabolism in Health and Disease. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s Principles of Internal Medicine. 16th edition. New York:MCGraw-Hill Companies; 2005. p. 2238-86
Wang H, Chen W, Li D, Yin X, Zhang X, Olsen N, Zheng SG. Vitamin D and Chronic Diseases. Aging Dis. 2017;8:346-353
Forsythe LK, Livingstone MB, Barnes MS, Horigan G, McSorley EM, Bonham MP, et al. Effect of adiposity on Vitamin D status and the 25-hydroxycholecalciferol response to supplementation in healthy young and older irish adults. Br J Nutr. 2012;107:126–34.
Barja-Fernandez S, Leis R, Casanueva FF, Seoane LM. Drug development strategies for the treatment of obesity: How to ensure efficacy, safety, and sustainable weight loss. Drug Des Devel Ther. 2014;8:2391–400
Walsh JS, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I,et al. Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. Am J Clin Nutr. 2016;103:1465-71.
Samuel, L. Borrell, L.N. The effect of body mass index on optimal vitamin D status in U.S. adults: the National Health and Nutrition Examination Survey 2001–2006. Ann. Epidemiol. 2013;23: 409–414
Baradaran A, Behradmanesh S, Nasri H. Association of body mass index and serum Vitamin D level in healthy Iranian adolescents. Endokrynol Pol. 2012;63:29–33.
Muscogiuri G, Sorice GP, Prioletta A, Policola C, Della Casa S, Pontecorvi A, et al. 25-hydroxyvitamin D concentration correlates with insulin-sensitivity and BMI in obesity. Obesity 2010;18:1906–10.
Costa P.R.F, Assis A.M.O, Santos C.A.S.T, Santos D.B, Pereira-Santos M, Pereira-Santos M, et al. Obesity and vitamin D deficiency: A systematic review and meta-analysis. Obes. Rev. 2015;16:341–349.
Wood R.J. Vitamin D and adipogenesis: New molecular insights. Nutr. Rev. 2008;66:40–46
Wamberg L, Kampmann U, Stødkilde-Jørgensen H, Rejnmark L, Pedersen S.B, Richelsen B. Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels—Results from a randomized trial. Eur. J. Intern. Med. 2013;24:644–649.
Kampmann U, Mosekilde L, Juhl C, Moller N, Christensen, Rejnmark L, et al. Effects of 12weeks high dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency—A double-blind, randomized, placebo-controlled trial. Metabolism. 2014;63:1115–1124.
Mason C, Xiao L, Imayama I, Duggan C, Wang C.-Y, Korde L, et al. Vitamin D3 supplementation during weight loss: A double-blind randomized controlled trial123. Am. J. Clin. Nutr. 2014;99:1015–1025
Khosravi ZS, Kafeshani M, Tavasoli P, Zadeh AH, Entezari MH. Effect of Vitamin D Supplementation on Weight Loss, Glycemic Indices, and Lipid Profile in Obese and Overweight Women: A Clinical Trial Study. Int J Prev Med. 2018;20:9:63
Perticone M, Maio R, Sciacqua A, Suraci E, Pinto A, Pujia R, et al. Ketogenic Diet-Induced Weight Loss is Associated with an Increase in Vitamin D Levels in Obese Adults. Molecules. 2019;9:24