How is NLR and PLR affected in Type 2 diabetes mellitus compared to healthy population? NLR and PLR affected in Type 2 diabetes mellitus

Main Article Content

Yavuz Dik


Objective: Diabetes Mellitus (DM); has become an important public health problem in Turkey and in the world. In this study, we aimed to investigate the effect of neutrophil / lymphocyte ratio and platelet / lymphocyte ratio in diabetic patients compared to healthy population in terms of cost effectiveness.

Material and Methods: A control group consisting of 82 diabetics and 85 healthy individuals who applied to the internal medicine outpatient clinic between January 2019 and November 2019 were included in the study. The patients were divided into two groups as those with diabetes and healthy individuals. Files were scanned retrospectively and hemoglobin, mean platelet volume (MPV), glycosylated hemoglobin (HbA1c), hematocrit counts (hct), neutrophil and lymphocyte counts, and neutrophil-lymphocyte ratio (NLR), platelet count (plt), platelet lymphocyte ratio (NLR) PLR) has been recorded.

Results: We retrospectively compared the demographic and laboratory parameters of the healthy group and the diabetic patients (82 patients and 85 healthy). The mean age of the diabetic group was 55.9 years, while the mean age of the healthy group was 37.5. Mean NLR was 2.4 and 2.1 in diabetic and healthy groups, respectively. NLR value was higher in diabetic group compared to healthy group and there was no statistically significant difference (p = 0.07). MPV values in diabetic group and healthy group were 8.53 and 8.51, respectively, and there was no significant relationship between them (p = 0.81). PLR value was 145.9 and 146.7 in diabetic group and healthy group, respectively, and we did not find any significant relationship (p = 0.97).

Discussion: As a result; In our study, when we evaluated the diabetic group within the diabetic group and the healthy group, we could not find a statistically significant relationship between the groups in terms of hematological parameters.


Download data is not yet available.

Article Details

How to Cite
DikY. (2020). How is NLR and PLR affected in Type 2 diabetes mellitus compared to healthy population?. Medical Science and Discovery, 7(2), 405-408.
Research Article


American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2005; 28: 37- 42. Diagnosis and classification of diabetes mellitus Diabetes Care 2007; 30: 42-47.

2. Tulgar YK, Cakar S, Tulgar S, et al. The effect of smoking on neutrophil/lymphocyte and platelet/lymphocyte ratio and platelet indices: a retrospective study. Eur. Rev. Med. Pharmacol. Sci. 2016;20: 3112–8.

3. Koh C-H, Bhoo-Pathy N, Ng K-L, et al. Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer. Br. J. Cancer. 2015;113:150–8.

4. Akdag S, Akyol A, Asker M, et al. Platelet-to-Lymphocyte Ratio May Predict the Severity of Calcific Aortic Stenosis. Med. Sci. Monit. 2015;21: 3395–3400.

5. Demirtas L, Degirmenci H, Akbas EM, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int. J. Clin. Exp. Med. 2015;8: 11420–7.

6. Yilmaz H, Ucan B, Sayki M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab. Syndr. 2015;9: 299–304.

7. Manabe I: Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ J 2011;75: 2739-48

8. Azab B, Zaher M, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, Gobunsuy R, Jadonath S, Baldari D, McCord D, Lafferty J: Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106:470-476

9. Chua W, Charles KA, Baracos VE, Clarke SJ: Neutrophil/ lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer. Br J Cancer 2011;104:1288-95

10. Onalan E, Gozel N, Donder E. Can hematological parameters in type 2 diabetes predict microvascular complication development? Pak J Med Sci. 2019 Nov-Dec;35(6):1511-1515. doi: 10.12669/pjms.35.6.1150.

11. Pitsavos C, Tampourlau M, Panagiotakos DB, Skoumas Y, Chrysohoou C, Nomikos T, et al. Association between low-grade systemic inflammation and type 2 diabetes mellitus among men and women from the ATTICA Study. Rev Diabet Stud 2007;4(2):98-104.

12. Bell DS, O’Keefe JH. White cell count, mortality, and metabolic syndrome in the Baltimore longitudinal study of aging. J Am Coll Cardiol 2007;50(18):1810-81.

13. Denghan A, Kardys I, de Maat MP, Uitterlinden AG, Sijbrands EJ, Bootsma AH, et al. Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes 2007;56(3): 872-8.

14. Onalan E, Gokalp Y. Evaluation of bone mineral density in geriatric age group with hematological parameters. Family Practice and Palliative Care. 2020;4(1): 1-5.

15. Baldane S, Ipekci SH, Kebapcilar A. Relationship Between Insulin Resistance and Mean Platelet Volume in Gestational Diabetes Mellitus. J. Lab. Physicians. 2015;7: 112–5.

16. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102(6): 653-7.

17. Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006;97(7): 993-6.

18. Tulgar YK, Cakar S, Tulgar S, et al. The effect of smoking on neutrophil/lymphocyte and platelet/lymphocyte ratio and platelet indices: a retrospective study. Eur. Rev. Med. Pharmacol. Sci. 2016;20: 3112–8.