Evaluation of Neutrophil, Lymphocyte, Platelet, Mean Platelet Volume, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio in Prostate Cancer Patients Treated with Radiotherapy Inflammatory Markers in Prostate Cancer Patient Treated with Radiotherapy

Main Article Content

Nurten Bahtiyar
Özlem Mermut

Abstract

Objective: Radiotherapy is a one cura­tive method for prostate cancer. Ionizing radiation can cause inflammation of tissues in and around the irradiated sites. But it is also suggested that low-dose radiation has anti-inflammatory effects. The present study was aimed at investigating the effects of radiotherapy on some inflammatory markers in prostate cancer patients.


Material and Methods: A total of 42 patients with prostate cancer and 30 healthy subjects were included in the present study. The day prior to radiotherapy (pre radiotherapy group) and the day radiotherapy was completed (post radiotherapy group) venous blood samples were collected. Neutrophil, lymphocyte, platelet, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) levels were detected.


Results: Neutrophil values of the pre radiotherapy group were higher than the control group (p<0.05), and values of the post radiotherapy group were lower than the pre radiotherapy group (p<0.001). Lymphocyte values of the post radiotherapy group were lower than the control, and the pre radiotherapy groups (p <0.001 for both). Platelet values were decreased in the post radiotherapy group compared to the pre radiotherapy group (p <0.01). MPV values of the pre radiotherapy group were higher than the control group (p<0.05), and were lower in the post radiotherapy group than the pre radiotherapy group (p <0.001). NLR and PLR values were decreased in the post radiotherapy group compared to the control group (p <0.001 for both), and were increased in post radiotherapy group compared to the pre radiotherapy group (p<0.001 for both).


Conclusion: Our findings showed that neutrophil, and MPV were increased in the pre radiotherapy group compared to the control group. Neutrophil, lymphocyte, platelet, and MPV were decreased, NLR and PLR were increased in the post radiotherapy group compared to the pre radiotherapy group.

Downloads

Download data is not yet available.

Article Details

How to Cite
BahtiyarN., & Mermut, Özlem. (2020). Evaluation of Neutrophil, Lymphocyte, Platelet, Mean Platelet Volume, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio in Prostate Cancer Patients Treated with Radiotherapy. Medical Science and Discovery, 7(5), 482-488. https://doi.org/10.36472/msd.v7i5.376
Section
Research Article

References

1. Cihan YB, Arslan A, Ergul MA. Subtypes of white blood cells in patients with prostate cancer or benign prostatic hyperplasia and healthy individuals. Asian Pacific Journal of Cancer Prevention. 2013;14(8):4779-4783.

2. Sfanos KS, De Marzo AM. Prostate cancer and inflammation: the evidence. Histopathology. 2012;60(1):199-215.

3. Langsenlehner T, Pichler M, Thurner E-M, et al. Evaluation of the platelet-to-lymphocyte ratio as a prognostic indicator in a European cohort of patients with prostate cancer treated with radiotherapy. Urologic Oncology: Seminars and Original Investigations, 2015; 33: 201.e9–201.e16.

4. Kemal Y, Yucel I, Ekiz K, et al. Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. Asian Pac J Cancer Prev. 2014;15(6):2651-2654.

5. Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331(6024):1565-1570.

6. Valga F, Monzón T, Henriquez F, Antón-Pérez G. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as biological markers of interest in kidney disease. Nefrología (English Edition). 2019.

7. Shrihari T. Dual role of inflammatory mediators in cancer. Ecancermedicalscience. 2017;11.

8. Mangalpally KKR, Siqueiros-Garcia A, Vaduganathan M, Dong J-F, Kleiman NS, Guthikonda S. Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro. Journal of thrombosis and thrombolysis. 2010;30(3):251-262.

9. Walsh S, Cook E, Goulder F, Justin T, Keeling N. Neutrophil‐lymphocyte ratio as a prognostic factor in colorectal cancer. Journal of surgical oncology. 2005;91(3):181-184.

10. Kılınçalp S, Ekiz F, Başar Ö, et al. Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer. Platelets. 2014;25(8):592-594.


11. Thavaramara T, Phaloprakarn C, Tangjitgamol S, Manusirivithaya S. Role of neutrophil to lymphocyte ratio as a prognostic indicator for epithelial ovarian cancer. Journal of the Medical Association of Thailand= Chotmaihet thangphaet. 2011;94(7):871-877.

12. Sharaiha RZ, Halazun KJ, Mirza F, et al. Elevated preoperative neutrophil: lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Annals of surgical oncology. 2011;18(12):3362-3369.

13. Zhang G-M, Zhu Y, Luo L, et al. Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy. Tumor Biology. 2015;36(11):8537-8543.

14. Li M, Li G-F, Hou X-Y, Gao H, Xu Y-G, Zhao T. A dosimetric comparison between conventional fractionated and hypofractionated image-guided radiation therapies for localized prostate cancer. Chinese medical journal. 2016;129(12):1447.

15. McKelvey KJ, Hudson AL, Back M, Eade T, Diakos CI. Radiation, inflammation and the immune response in cancer. Mammalian genome. 2018;29(11-12):843-865.

16. Treffers LW, Hiemstra IH, Kuijpers TW, Van den Berg TK, Matlung HL. Neutrophils in cancer. Immunological reviews. 2016;273(1):312-328.

17. Li X, Yan Z, Wang R, Yu K. Preoperative Mean Platelet Volume and Platelet Distribution Width Predict Postoperative Sepsis in Patients with Colorectal Cancer. BioMed research international. 2019;2019.













































18. Song X, Chen D, Yuan M, Wang H, Wang Z. Total lymphocyte count, neutrophil–lymphocyte ratio, and platelet–lymphocyte ratio as prognostic factors in advanced non–small cell lung cancer with chemoradiotherapy. Cancer management and research. 2018;10:6677.

19. Yaylaci S, Tosun O, Sahin O, et al. Lack of variation in inflammatory hematological parameters between benign nodular goiter and papillary thyroid cancer. Asian Pacific Journal of Cancer Prevention. 2016;17(4):2321-2323.

20. Chung E, Biswas T. Change in the Neutrophil-to-Lymphocyte Ratio (NLR) Pre and Post Stereotactic Body Radiation Treatment (SBRT) for Stage I Non-Small Cell Lung Cancer (NSCLC): Is There a Clinical Significance? International Journal of Radiation Oncology• Biology• Physics. 2018;102(3):e679.

21. Son SH, Park EY, Park HH, Kay CS, Jang HS. Pre-radiotherapy neutrophil-to-lymphocyte ratio as an independent prognostic factor in patients with locally advanced hepatocellular carcinoma treated with radiotherapy. Oncotarget. 2017;8(10):16964.

22. dos Santos M da SF, Lundgren M do S de M, Cavalcanti D de AS. Weekly monitoring of the effects of conventional external beam radiation therapy on patients with head and neck, chest, and pelvis cancer by means of blood cells count. 2008.

23. Wu Z, Zhang J, Cai Y, et al. Reduction of circulating lymphocyte count is a predictor of good tumor response after neoadjuvant treatment for rectal cancer. Medicine. 2018;97(38).