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Objective: Studies showed that cerebral ischemia due to arterial occlusion is related to local inflammation. Neutrophil to Lymphocyte Ratio (N/L) and Monocyte to high density lipoprotein Cholesterol Ratio (M/H) are two biomarkers that are shown to be increased in inflammation. These biomarkers can be used to determine the risk for atherosclerotic ischemic stroke. Increased Homocysteinemia (Hcy) is also a risk factor for ischemic stroke, especially in the young population. There is insufficient data in the literature about the correlation of these biomarkers in young stroke patients.
We aimed to show if these biomarkers can be related to atherothrombotic cerebrovascular disease in the young population to provide information for young people to stroke risk.
Study design and method: This retrospective study included 43 atherosclerotic ischemic young stroke patients, age between 18- 55 years and age/ gender matched 42 healthy control group. Control group were enrolled from patients who were admitted to our outpatient clinics with headaches, having normal examinations and no other diseases.
Results: The ratios of N/L and M/H were both higher in the stroke group (p=0.008 and p=0.011 respectively), but the gender subanalysis showed there was no significance in the males. When the patients were sub-grouped as having hyper Hcy or not; these ratios did not show any significance.
Conclusion: Inflammatory biomarkers should be interpreted carefully by concerning the age and the gender of the patients. Further studies with large sample groups are necessary for the biomarkers of young stroke population.
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