Pre and post-operative oxidative stress level in cases with ovarian neoplasia
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Objective: The aim of this study is to analyze the serum antioxidant enzyme activities and oxidative stress levels in patients with ovarian neoplasia. Oxidative stress is considered to play a role in the pathogenesis of many diseases such as cancer, diabetes and heart condition. Antioxidants are involved in the removal of carcinogen lipid soluble radicals produced by lipid peroxidation. Material and Methods: In his study, pre and post-operative serum glutathione (GSH), superoxide dismutase (SOD), serum catalase (CAT) activity, and malondialdehyde (MDA) levels were investigated in the patient with with ovarian neoplasia. Results: The reduced serum glutathione (GSH) activity was observed to decrease in patients with ovarian cancer (p
Hybertson BM, Gao B, Bose SK, McCord JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Molecular aspects of medicine. 2011;32(4-6):234-46.
Pirincci N, Kaba M, Gecit I, Gunes M, Yuksel MB, Tanik S, et al. Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma. Toxicology and industrial health. 2013.
McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). The Journal of biological chemistry. 1969;244(22):6049-55.
Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. The Journal of laboratory and clinical medicine. 1963;61:882-8.
Aebi H. Catalase in vitro. Methods in enzymology. 1984;105:121-6.
Kopani M, Celec P, Danisovic L, Michalka P, Biro C. Oxidative stress and electron spin resonance. Clinica chimica acta; international journal of clinical chemistry. 2006;364(1-2):61-6.
Koca N, Karadeniz F. Serbest radikal oluşum mekanizmalari ve vücuttaki antioksidan savunma sistemleri. Gıda Muh.Dergisi, Ankara. 2014;32-37.
Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000;148(2-3):187-97.
Gökpinar Ş, Kora, T, Akçiçek E, Göksan T, Durmaz Y. Algale antioxidants. Ege Ünivesitesi. Aqua Culture Magazine. 2006;23:85-89.
Sehitogullari A, Aslan M, Sayir F, Kahraman A, Demir H. Serum paraoxonase-1 enzyme activities and oxidative stress levels in patients with esophageal squamous cell carcinoma. Redox report : communications in free radical research. 2014;19(5):199-205.
Sprem M, Babic D, Abramic M, Vrhovec I, Skrk J, Milicic D, et al. Glutathione and glutathione S-transferases as early markers for ovarian carcinomas: case series. Croatian medical journal. 2001;42(6):624-9.
Abou Ghalia AH, Fouad IM. Glutathione and its metabolizing enzymes in patients with different benign and malignant diseases. Clinical biochemistry. 2000;33(8):657-62.