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Objective: Endothelial dysfunction is the primary initial step for atherogenesis in cardiovascular disease. Stable angina pectoris is a stable form of cardiovascular disease that profoundly alters Endothelial Progenitor Cells (EPC) and Circulating Endothelial Cells (CEC). Both CEC and EPC have a significant role as native homeostasis biomarker of endothelial, which could initiate cytokine storm when homeostasis was altering. Ganoderma Lucidum is known for the antioxidative, anti-inflammatory, and anti-cancer properties and indirect anti endothelial dysfunction. The previous study has proven the Polysaccharide Peptide (PsP) of Ganoderma Lucidum as an effective antioxidant and anti-endothelial dysfunction in atherosclerosis rats and shows no toxicity in an animal model. This study goals to prove the effect of PsP in CEC and EPC in stable angina patients.
Methods: This is a quasi-experimental trial of 35 Stable Angina patients, determined based on ESC Stable CAD Guidelines with pre and post-test design without a control group. The parameters are CEC and EPC counts. The patients were given PsP 750mg/day in 3 divided doses for 90 days. A paired t-test perform for normally distributed data, and the Wilcoxon test for not normally distributed data, and a significant level of p≤0,05.
Results: CEC significantly reduced in stable angina patients, with p=0,001. EPC count significantly reduced in stable angina with p=0,001.
Conclusion: Ganoderma Lucidum PsP is a potent anti-endothelial dysfunction against atherosclerosis's pathogenesis in stable angina.
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