Anaplastic Childhood Meningioma in a 16-Year-Old Boy
Main Article Content
Meningiomas account for 0.4-4.6% of all primary brain tumors in children. Childhood meningiomas have several different characteristics than those occurring in adults. Case: Here we report a 16 year old male presented with long-standing headache and incipient weakness on the left side. Magnetic resonance images revealed a 65x47x37 mm sized, right sided frontoparietal parasagittal extra-axial mass. Histopathologic examination showed monotonous, small cells with oval/round nucleus forming whorl-like structures. The tumor showed high mitotic index and Ki67 proliferation rate around 30%. Immunohistochemically tumor cells were positive with EMA, vimentin, BCL-2, progesterone receptor. The final diagnosis according to histopathological, radiological and immunohistochemical findings was anaplastic meningioma. Conclusion: High-grade meningiomas are rare in children. Appropriate grading is important, as high grade tumors with high proliferation index are associated with less favorable clinical outcomes and warrant more radical treatment.
Kotecha RS, Junckerstorff RC, Lee S, Cole CH, Gottardo NG. Pediatric meningioma: current approaches and future direction. Journal of neuro-oncology. 2011;104(1):1-10.
Mekitarian Filho E, Horigoshi NK, Carvalho WB, Hirscheimer MR, Bresolin AU, Leme RJ, et al. Primary spinal meningioma in a 10-year-old boy. Arquivos de neuro-psiquiatria. 2010;68(5):804-6.
Riemenschneider MJ, Perry A, Reifenberger G. Histological classification and molecular genetics of meningiomas. The Lancet Neurology. 2006;5(12):1045-54.
Liu Y, Li F, Zhu S, Liu M, Wu C. Clinical features and treatment of meningiomas in children: report of 12 cases and literature review. Pediatric neurosurgery. 2008;44(2):112-7.
Menon G, Nair S, Sudhir J, Rao BR, Mathew A, Bahuleyan B. Childhood and adolescent meningiomas: a report of 38 cases and review of literature. Acta neurochirurgica. 2009;151(3):239-44; discussion 44.
Arivazhagan A, Devi BI, Kolluri SV, Abraham RG, Sampath S, Chandramouli BA. Pediatric intracranial meningiomas--do they differ from their counterparts in adults? Pediatric neurosurgery. 2008;44(1):43-8.
Gao X, Zhang R, Mao Y, Wang Y. Childhood and juvenile meningiomas. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2009;25(12):1571-80.
Greene S, Nair N, Ojemann JG, Ellenbogen RG, Avellino AM. Meningiomas in children. Pediatric neurosurgery. 2008;44(1):9-13.
Kotecha RS, Pascoe EM, Rushing EJ, Rorke-Adams LB, Zwerdling T, Gao X, et al. Meningiomas in children and adolescents: a meta-analysis of individual patient data. The Lancet Oncology. 2011;12(13):1229-39.
Kohama I, Sohma T, Nunomura K, Igarashi K, Ishikawa A. Intraparenchymal meningioma in an infant--case report. Neurologia medico-chirurgica. 1996;36(8):598-601.
Santos MV, Furlanetti L, Valera ET, Brassesco MS, Tone LG, de Oliveira RS. Pediatric meningiomas: a single-center experience with 15 consecutive cases and review of the literature. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2012;28(11):1887-96.
Wang XQ, Jiang CC, Zhao L, Gong Y, Hu J, Chen H. Erratum: Clinical features and treatment of World Health Organization Grade II and III meningiomas in childhood: report of 23 cases. Journal of neurosurgery Pediatrics. 2012;10(5):459.