Main Article Content
Objective: Aim of the study was to study in parallel changes in electrogustometric thresholds (EGM), in morphology and density of the fungiform papillae (fPap) and in vessels’ shape and density at the tip of the human tongue of patients receiving Captopril.
Material and Methods: In 18 female subjects receiving Captopril (50mg, once per day) as Monotherapy against Hypertension EGM thresholds at the chorda tympani, at the soft palate were recorded bilaterally. Morphology and density of the fungiform papillae (fPap) and blood vessels’ density and morphology at the tip of the tongue were examined using contact endoscopy (CE). As control-group 18 healthy non-smokers female subjects of the same age group were also examined.
Results: The evaluation of subjects treated with Captopril showed a higher EGM-thresholds as the subjects of the control-group. The difference between the density of patients’ fPap and that of the control-group was statistically significant. It is obvious that Captopril affects the shape and the vascularization of fPap. Captopril can affect seriously taste acuity.
Conclusion: The present study provides data concerning the simultaneous changes in both EGM-Thresholds and shape and vascularization of fPap. The use of captopril seems to have a negative effect on them.
Keywords: Captopril, contact endoscopy, electrogustometry, fungiform papillae, vascularization
Tomita H, Yoshikawa T. Drug-related taste disturbances. Acta Otolaryngol Suppl. 2002, 546: 116-121.
Henkin RI. Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction. Drug Saf.1994; 11(5):318–377.
Unnikrishnan D, Murakonda P, Dharmarajan TS. 2004. If it is not cough, it must be dysgeusia: differing adverse effects of angiotensin-converting enzyme inhibitors in the same individual. J Am Med Dir Assoc. 2004; 5(2):107-110.
Boucher Y, Berteretche M.V, Fahrang F, Avry MP, Azerad J, Faurion A. Taste deficits related to dental deafferentation: an electrogustometric study in humans. 2006. 114(6): 456-464.
Negoro A, Umemoto M, Fukazawa K, Terada T, Sakagami M. Observation of tongue papillae by video microscopy and contact endoscopy to investigate their correlation with taste function. Auris Nasus Larynx. 2004; 31(3): 255-259.
Ackermann BH, Kasbekar N. Disturbances of taste and smell induced by drugs. Pharmacotherapy. 1997. 17(3): 482-496.
Schiffman S. Taste and smell in disease. New Engl J Med. 1983; 308(22): 1275–1279.
Heyneman CA. Zinc deficiency and taste disorders. Ann Pharmacother. 1996 30(2): 186–187.
Gilbertson T, Damak S, Margolskee R. The molecular physiology of taste transduction. Curr Opin Neurobiol.2000; 10(4): 519–527.
Tsuruoka S, Wakaumi M, Nishiki K, Araki N, Harada K, Sugimoto K, Fujimura A. Br J Clin Pharmacol. 2004; 57(6): 807-812.
Takeda N, Takaoka T, Ueda C, Toda, Kalubi B, Yamamoto S. Zinc deficiency in patients with idiopathic taste impairment with regard to angiotensin converting enzyme activity. Auris Nasus Larynx. 2004; 31(4): 425-428.
Van Wouwe JP. Clinical and laboratory assessment of zinc deficiency in Dutch Children. 1995; 49(2-3):211-225.
Just T, Pau WH, Witt M, Hummel T. Contact Endoscopic Comparison of Morphology of Human Fungiform Papillae of Healthy Subjects and Patients with Transected Chorda Tympani Nerve. Laryngoscope. 2006; 116(7): 1216-1222.
Pavlidis P, Gouveris H, Gorgulla H, Hast HJ, Maurer J. Electrogustometry and contact endoscopic findings in patients with head and neck malignancies treated with chemotherapy, radiotherapy or radiochemotherapy. Chem Senses 2015;40(3):165-171.
Pavlidis P, Cámara RJA, Kekes G, Gouveris H. Bilateral taste disorders in patients with Ramsay Hunt syndrome and Bell palsy. Ann Neurol 2018;83(4):807-815.
Pavlidis P, Gouveris H, Kekes G. Electrogustometry Thresholds, Tongue Tip Vascularization, Density, and Form of the Fungiform Papillae Following Smoking Cessation. Chem Senses. 2017;42(5):419-423.
Chou HC, Chien CL, Huang HL, Lu KS. 2001. Effects of zinc deficiency on the vallate papillae and taste buds in rats. J Formos Med Assoc. 100(5): 326-335.
Miller IJ and Reedy FE. Variations in Human Taste Bud Density and Taste Intensity Perception. 1990. Physiol Behav. 47(6): 1213-1219.
Ikeda M, Tomita H. Changes in soft palate taste buds of rats due to aging and zinc deficiency-scanning electron microscopic observation. 1988. Auris Nasus Larynx. 15(2): 117-127.