Investigation of association between ABO blood groups and COVID-19 clinical severity

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Arzu İrvem
Abdurrahman Sarmış
Özlem Akgün Doğan
Jale Yıldız
Zafer Habib
Nihat Buğra Ağaoğlu
Betsi Köse
Gizem Alkurt
Lütfiye Nilsu Altunal
Ayşe Serra Özel
Mehtap Aydın
Sanem Dereli Bulut
Yasemin Kendir Demirkol
Esra Koçoğlu
Gizem Dinler Doğanay
Levent Doğanay
Yaşar Bükte
Sebahat Aksaray

Abstract

Objective: COVID-19 has been detected in Turkey since March 11, 2020. Istanbul has become an important center of the pandemic in Turkey. Various risk factors for COVID-19 infection, mortality, and morbidity are under investigation. Recent studies have suggested that certain blood groups are risk factors for the disease. The aim of this study is the evaluation the relationship between blood groups and the risk of contracting COVID-19 disease, clinical severity of the disease, and CT (computed tomography) imaging findings.


Material and Methods: Age, gender, blood group data, clinical severity and CT images of 300 patients who were positive with RT PCR (Reverse transcription-polymerase chain reaction) and were followed up in the clinic were retrospectively scanned and recorded. The clinical severity of the disease and CT imaging findings were scored, and the data were evaluated statistically.


Results: While the incidence of COVID-19 was high in the A blood group, it was low in the 0 blood group. Although there was no significant difference between blood types and clinical severity, the involvement in the B blood group was more severe on CT imaging.


Conclusion: People with A blood group should pay more attention to protection and isolation. Investigating this difference and underlying pathogenic mechanisms can guide science with advanced studies.

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How to Cite
İrvem, A., Sarmış, A. ., Doğan, Özlem A. ., Yıldız, J., Habib, Z., Ağaoğlu, N. B. ., Köse, B., Alkurt, G., Altunal, L. N. ., Özel, A. S. ., Aydın, M. ., Bulut, S. D. ., Demirkol, Y. K. ., Koçoğlu, E. ., Doğanay, G. D. ., Doğanay, L., Bükte, Y. ., & Aksaray, S. . (2021). Investigation of association between ABO blood groups and COVID-19 clinical severity. Medical Science and Discovery, 8(12), 671–674. https://doi.org/10.36472/msd.v8i12.550
Section
Research Article

References

Mohan BS, Nambiar V. COVID-19: An Insight into SARS-CoV-2 Pandemic Originated at Wuhan City in Hubei Province of China. J Infect Dis Epidemiol. 2020; 146 :6 ( 4).

Wu B.B., Gu D.Z., Yu J.N, Yang J, and Shen W.Q. Association between ABO blood groups and COVID-19 infection, severity and demise: A systematic review and meta-analysis. Infect Genet Evol. 2020; 84: 104485. doi: 10.1016/j.meegid.2020.104485

https://www.kizilay.org.tr/

Dogan OA, Kose B, Agaoglu NB, Yildiz J, Alkurt G, Demirkol YK, Irvem A, Doganay GZ, L Doganay. Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR? Comparing saliva with oro-nasopharyngeal swabs. Journal of Virological Methods.2021; 290: 114049

Zhao J., Yang Y., Huang H.P. Relationship between the ABO blood group and the COVID-19 susceptibility. medRxiv. 2020;2020 doi: 10.1101/2020.03.11.20031096. 03.11.20031096.

Zietz M., Tatonetti N.P. Testing the association between blood type and COVID-19 infection, intubation, and death. medRxiv. 2020. doi: 10.1101/2020.04.08.20058073.

Cooling L. Blood groups in infection and host susceptibility. Clin Microbiol Rev. 2015;28(3):801–870. doi: 10.1128/cmr.00109-14.

Walls A., Park Y., Tortorici M., Wall A., McGuire A., Veesler D. Structure, function, and Antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181(2):281–292. doi: 10.1016/j.cell.2020.02.058. e6.

Yamamoto. Fumiichiro. ABO blood groups and SARS-CoV-2 infection. Immunohematology & Glycobiology Laboratory Josep Carreras Leukaemia Research Institute. 2020.

Ellinghaus D, Degenhardt F, Bujanda L. Buti M , Albillos A, Invernizzi P et al. The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis. JAMA. 2005; 293(12) doi: 10.1101/2020.05.31.20114991

Gérard C., Maggipinto G., Minon JM. COVID-19 and ABO blood group: another viewpoint. Br J Haematol. 2020 ;190(2):e93-e94. doi: 10.1111/bjh.16884. Epub 2020 Jun 8

Dai X. ABO blood group predisposes to COVID-19 severity and cardiovascular diseases. Eur J Prev Cardiol. 2020 ; 27(13): 1436–1437.