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Breast Cancer: Treatment Effects on Fertility and Subsequent Pregnancy Outcomes
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Published:
Aug 19, 2021
Versions:
2021-08-19 (1)
Keywords:
breast cancer, fertility, pregnancy, treatment
Main Article Content
Abstract
Objective: Breast cancer is the most common cancer type in women of reproductive age. Given that most women postpone childbearing, breast cancer occurrence possibly perplexes their plans for starting a family. The treatment for breast cancer can affect their fertility and have adverse effects on a pregnancy that occurs during that period. The aim of this narrative review is primarily to explore the influence of breast cancer therapy on the ability of a woman diagnosed with breast cancer to gestate. Moreover, to determine the safer timing for childbearing after being treated for breast cancer and investigate the pregnancy outcome when conception is succeeded.
Childbearing after treatment for breast cancer is considered safe and pregnancy outcomes are favorable if conception happens 1 year after chemotherapy or at least 2 years after chemotherapy and radiation therapy. Counseling is of great significance and fertility preservation methods should be thoroughly discussed with women diagnosed with breast cancer, even prior to commencement of the treatment
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How to Cite
Sarantaki, A., & Perisaki, K. (2021). Breast Cancer: Treatment Effects on Fertility and Subsequent Pregnancy Outcomes. Medical Science and Discovery, 8(8), 442–447. https://doi.org/10.36472/msd.v8i8.587
Section
Review Article
Received 2021-08-02
Accepted 2021-08-14
Published 2021-12-09
Accepted 2021-08-14
Published 2021-12-09
References
References
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2. Braems G, Denys H, De Wever O, Cocquyt V, Van den Broecke R. Use of tamoxifen before and during pregnancy. The oncologist. 2011;16(11), 1547–1551. https://doi.org/10.1634/theoncologist.2011-0121
3. Slepicka P. F., Cyrill S. L., Dos Santos C. O. Pregnancy and Breast Cancer: Pathways to Understand Risk and Prevention. Trends in molecular medicine. 2019; 25(10), 866–881. https://doi.org/10.1016/j.molmed.2019.06.003.
4. Shah NM, Scott DM, Kandagatla P, Moravek MB, Cobain EF, Burness ML, Jeruss, JS. Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer. Annals of surgical oncology. 2019;26(5), 1214–1224. https://doi.org/10.1245/s10434-019-07156-7.
5. Nye L, Rademaker A, Gradishar WJ. Breast Cancer Outcomes After Diagnosis of Hormone-positive Breast Cancer and Subsequent Pregnancy in the Tamoxifen Era. Clinical breast cancer. 2017;17(4), e185–e189. https://doi.org/10.1016/j.clbc.2016.12.014.
6. Helewa M, Lévesque P, Provencher D, Lea RH, Rosolowich V, Shapiro HM. Breast Disease Committee and Executive Committeee and Council, Society of Obstetricians and Gynaecologists of Canada Breast Cancer. Pregnancy, and Breastfeeding Journal of Obstetrics and Gynaecology Canada 2002;24(2): 164-171 https://doi.org/10.1016/S1701-2163(16)30298-5
7. BreastCancer.org. 2014 Fertility after Radiation Therapy. [online]. Available at: https://www.breastcancer.org/tips/fert_preg_adopt/treatments/radiation.
8. Ter Welle-Butalid M, Vriens I, Derhaag J, Leter E, de Die-Smulders C, Smidt MM, van Golde R, Tjan-Heijnen V. Counseling young women with early breast cancer on fertility preservation. Journal of assisted reproduction and genetics. 2019;36(12), 2593–2604. https://doi.org/10.1007/s10815-019-01615-6.
9. American Cancer Society 2019. Chemotherapy for Breast Cancer. [online]. Available at: https://www.cancer.org/cancer/breast-cancer/treatment/chemotherapy-for-breast-cancer.html.
10. Lambertini M, Del Mastro L, Pescio MC, Andersen CY, Azim HA Jr, Peccatori FA, Costa M, Revelli A, Salvagno F, Gennari A, Ubaldi FM, La Sala GB, De Stefano C, Wallace WH, Partridge AH, Anserini P.Cancer and fertility preservation: international recommendations from an expert meeting. BMC medicine. 2016;14(1). [online]. Available at: https://doi.org/10.1186/s12916-015-0545-7.
11. European Society for Medical Oncology (ESMO) 2020. Pregnancy Is Safe After Early Breast Cancer In Young Women With Germline BRCA Mutations. ESMO. [online] Available at: https://www.esmo.org/oncology-news/pregnancy-is-safe-after-early-breast-cancer-in-young-women-with-germline-brca-mutations.
12. Sukumvanich P, Case LD, Van Zee K, Singletary SE, Paskett ED, Petrek JA. Incidence and time course of bleeding after long-term amenorrhea after breast cancer treatment: a prospective study. Cancer. 2010; 116:3102–11 https://doi.org/10.1002/cncr.25106
13. Anderson RA, Themmen AP, Al-Qahtani A, Groome NP, Cameron DA. The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer. Hum Reprod. 2006; 21(10):2583–92 https://doi.org/10.1093/humrep/del201
14. Hartnett KP, Mertens AC, Kramer MR, Lash TL, Spencer JB, Ward KC, Howards PP. Pregnancy after cancer: Does timing of conception affect infant health? American Cancer Society Journals: Cancer. 2018;124(22), 4401–4407. https://doi.org/10.1002/cncr.31732.
15. Buonomo B, Brunello A, Noli S, Miglietta L, Del Mastro L, Lambertini M, Peccatori FA. Tamoxifen Exposure during Pregnancy: A Systematic Review and Three More Cases. Breast care (Basel, Switzerland). 2020;15(2), 148–156. https://doi.org/10.1159/000501473.
16. Lee MH, Kim YA, Hong JH, Jung SY, Lee S, Kong SY, Park B, Lee ES. Outcomes of Pregnancy after Breast Cancer in Korean Women: A Large Cohort Study. Cancer research and treatment: official journal of Korean Cancer Association. 2020;52(2), 426–437. https://doi.org/10.4143/crt.2018.382.
17. Knabben L, Mueller MD. Breast cancer and pregnancy. Horm Mol Biol Clin Investig. 2017; 32(1). doi:10.1515/hmbci-2017-0026
18. Gerstl B, Sullivan E, Ives A, Saunders C, Wand H, Anazodo A. Pregnancy Outcomes After a Breast Cancer Diagnosis: A Systematic Review and Meta-analysis. Clinical Breast Cancer.2018 Feb;18(1): e79-e88 https://doi.org/10.1016/j.clbc.2017.06.016
19. Rosenberg J. American Society of Clinical Oncology (ASCO) (2018). 2018 ASCO Guideline Update: Fertility Preservation in Patients with Cancer. https://www.ajmc.com/view/2018-asco-guideline-update-fertility-preservation-in-patients-with-cancer
20. Harada M, Osuga Y. Fertility preservation for female cancer patients. Int J Clin Oncol. 2019 Jan;24(1):28-33. doi: 10.1007/s10147-018-1252-0
21. Razeti MG, Spinaci S, Spagnolo F, Massarotti C, Lambertini M. How I perform fertility preservation in breast cancer patients. ESMO Open. CANCER HORIZONS. 2021 Jun;6(3):100112 https://doi.org/10.1016/j.esmoop.2021.100112
1. Kalogerakos K, Sofoudis C, Tzonis P, Koutsouradis P, Katsoulis G. Breast cancer and pregnancy; overview of international bibliography. Journal of BUON.: official journal of the Balkan Union of Oncology. 2013;18(2):308–313. https://pubmed.ncbi.nlm.nih.gov/23818339/
2. Braems G, Denys H, De Wever O, Cocquyt V, Van den Broecke R. Use of tamoxifen before and during pregnancy. The oncologist. 2011;16(11), 1547–1551. https://doi.org/10.1634/theoncologist.2011-0121
3. Slepicka P. F., Cyrill S. L., Dos Santos C. O. Pregnancy and Breast Cancer: Pathways to Understand Risk and Prevention. Trends in molecular medicine. 2019; 25(10), 866–881. https://doi.org/10.1016/j.molmed.2019.06.003.
4. Shah NM, Scott DM, Kandagatla P, Moravek MB, Cobain EF, Burness ML, Jeruss, JS. Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer. Annals of surgical oncology. 2019;26(5), 1214–1224. https://doi.org/10.1245/s10434-019-07156-7.
5. Nye L, Rademaker A, Gradishar WJ. Breast Cancer Outcomes After Diagnosis of Hormone-positive Breast Cancer and Subsequent Pregnancy in the Tamoxifen Era. Clinical breast cancer. 2017;17(4), e185–e189. https://doi.org/10.1016/j.clbc.2016.12.014.
6. Helewa M, Lévesque P, Provencher D, Lea RH, Rosolowich V, Shapiro HM. Breast Disease Committee and Executive Committeee and Council, Society of Obstetricians and Gynaecologists of Canada Breast Cancer. Pregnancy, and Breastfeeding Journal of Obstetrics and Gynaecology Canada 2002;24(2): 164-171 https://doi.org/10.1016/S1701-2163(16)30298-5
7. BreastCancer.org. 2014 Fertility after Radiation Therapy. [online]. Available at: https://www.breastcancer.org/tips/fert_preg_adopt/treatments/radiation.
8. Ter Welle-Butalid M, Vriens I, Derhaag J, Leter E, de Die-Smulders C, Smidt MM, van Golde R, Tjan-Heijnen V. Counseling young women with early breast cancer on fertility preservation. Journal of assisted reproduction and genetics. 2019;36(12), 2593–2604. https://doi.org/10.1007/s10815-019-01615-6.
9. American Cancer Society 2019. Chemotherapy for Breast Cancer. [online]. Available at: https://www.cancer.org/cancer/breast-cancer/treatment/chemotherapy-for-breast-cancer.html.
10. Lambertini M, Del Mastro L, Pescio MC, Andersen CY, Azim HA Jr, Peccatori FA, Costa M, Revelli A, Salvagno F, Gennari A, Ubaldi FM, La Sala GB, De Stefano C, Wallace WH, Partridge AH, Anserini P.Cancer and fertility preservation: international recommendations from an expert meeting. BMC medicine. 2016;14(1). [online]. Available at: https://doi.org/10.1186/s12916-015-0545-7.
11. European Society for Medical Oncology (ESMO) 2020. Pregnancy Is Safe After Early Breast Cancer In Young Women With Germline BRCA Mutations. ESMO. [online] Available at: https://www.esmo.org/oncology-news/pregnancy-is-safe-after-early-breast-cancer-in-young-women-with-germline-brca-mutations.
12. Sukumvanich P, Case LD, Van Zee K, Singletary SE, Paskett ED, Petrek JA. Incidence and time course of bleeding after long-term amenorrhea after breast cancer treatment: a prospective study. Cancer. 2010; 116:3102–11 https://doi.org/10.1002/cncr.25106
13. Anderson RA, Themmen AP, Al-Qahtani A, Groome NP, Cameron DA. The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer. Hum Reprod. 2006; 21(10):2583–92 https://doi.org/10.1093/humrep/del201
14. Hartnett KP, Mertens AC, Kramer MR, Lash TL, Spencer JB, Ward KC, Howards PP. Pregnancy after cancer: Does timing of conception affect infant health? American Cancer Society Journals: Cancer. 2018;124(22), 4401–4407. https://doi.org/10.1002/cncr.31732.
15. Buonomo B, Brunello A, Noli S, Miglietta L, Del Mastro L, Lambertini M, Peccatori FA. Tamoxifen Exposure during Pregnancy: A Systematic Review and Three More Cases. Breast care (Basel, Switzerland). 2020;15(2), 148–156. https://doi.org/10.1159/000501473.
16. Lee MH, Kim YA, Hong JH, Jung SY, Lee S, Kong SY, Park B, Lee ES. Outcomes of Pregnancy after Breast Cancer in Korean Women: A Large Cohort Study. Cancer research and treatment: official journal of Korean Cancer Association. 2020;52(2), 426–437. https://doi.org/10.4143/crt.2018.382.
17. Knabben L, Mueller MD. Breast cancer and pregnancy. Horm Mol Biol Clin Investig. 2017; 32(1). doi:10.1515/hmbci-2017-0026
18. Gerstl B, Sullivan E, Ives A, Saunders C, Wand H, Anazodo A. Pregnancy Outcomes After a Breast Cancer Diagnosis: A Systematic Review and Meta-analysis. Clinical Breast Cancer.2018 Feb;18(1): e79-e88 https://doi.org/10.1016/j.clbc.2017.06.016
19. Rosenberg J. American Society of Clinical Oncology (ASCO) (2018). 2018 ASCO Guideline Update: Fertility Preservation in Patients with Cancer. https://www.ajmc.com/view/2018-asco-guideline-update-fertility-preservation-in-patients-with-cancer
20. Harada M, Osuga Y. Fertility preservation for female cancer patients. Int J Clin Oncol. 2019 Jan;24(1):28-33. doi: 10.1007/s10147-018-1252-0
21. Razeti MG, Spinaci S, Spagnolo F, Massarotti C, Lambertini M. How I perform fertility preservation in breast cancer patients. ESMO Open. CANCER HORIZONS. 2021 Jun;6(3):100112 https://doi.org/10.1016/j.esmoop.2021.100112