Can changes in platelet count, mean platelet volume, and platelet distribution width be used to determine the severity of COVID-19?

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Yasin Tire
Mehmet Akif Yazar
Said Sami Erdem


Objective: We aimed to investigate the relation of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) with other acute phase reactants in COVID-19 new corona virus.

Material and Methods: Thirty one patients with COVID-19 were included in to study. There were three groups as outpatient (Group 1, OP)(n=6), hospital (Group 2, H)(n=16) and intensive care unit (Group 3, IC)(n=9) in this analytic study.

Results: WBC (White Blood Cell), CRP (C-Reactive Protein) values were significantly different in all groups. PDW values were significantly lower in Group 3 than Group 1, 2. The result of ROC analysis was 10.9 as a cut-off value (Area under the curve, AUC)=0.407)

Conclusions: This study indicates that lower PDW may frequently develop in COVID-19 cases and there is a relation between thrombocytosis and acute phase reactants, that is, the inflammatory response. So we can offer that PDW should be used as a marker of Covid-19 disease severity, but it needs more studies in the future.


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How to Cite
Tire, Y., Yazar, M. A., & Erdem, S. S. (2021). Can changes in platelet count, mean platelet volume, and platelet distribution width be used to determine the severity of COVID-19?. Medical Science and Discovery, 8(10), 581–585.
Research Article
Received 2021-09-22
Accepted 2021-10-11
Published 2021-10-14


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