The effect of insulin resistance on inflammation markers in individuals with obesity
Main Article Content
Objective: Obesity has recently been recognized as a chronic low-grade inflammation condition. We aimed to compare the predictive values of insulin resistance and inflammatory indices in individuals with obesity.
Materials and Methods: 124 people who had a health check for obesity-related risk factors in our hospital between June 2018 and September 2019 were included in the study. Inflammatory markers of the patients were evaluated.
Results: The study group consists of a total of 224 people, and we compared the demographic data and laboratory parameters of the individuals. C-reactive protein (CRP) levels of obese individuals were statistically higher than those with normal body mass index (p <0.001). There was no statistically significant difference between the groups in terms of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values, among other inflammation markers. A positive and statistically significant correlation was found between body mass index and CRP level (r = 0.334, p <0.001). There was no significant correlation between body mass index and NLR and PLR.
Conclusion: As a result, CRP levels of obese individuals were statistically higher than individuals with normal body mass index. No statistically significant difference was found between the groups in terms of NLR and PLR values among other inflammation markers.
World Health Organization.Obesity: Preventing and Managing the Global Epidemic. Geneva: The World Health Organization; 2000. Technical Report Series no. 894.
Mendez MA, Monteiro CA, Popkin BM. Overweight exceeds underweight among women in most developing countries. Am J Clin Nutr 2005;81:714–21.
Johnson AR, Justin Milner J, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev 2012;249:218–38. [PMC free article] [PubMed] [Google Scholar]
Dasu MR, Jialal I. Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab 2011;300:E145–54. [PMC free article] [PubMed] [Google Scholar]
Glass CK, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab 2012;15:635–45. [PMC free article] [PubMed] [Google Scholar]
Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011;121:2111–7. [PMC free article] [PubMed] [Google Scholar]
Cefalu WT. Insulin resistance: cellular and clinical concepts. Exp Biol Med (Maywood) 2001;226:13-26.
Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012;148:852-71.
Christos Matzoros.Insülin resistance:Definition and clinical spectrum. http://www.uptodate.com 2012.
Insulin resistance. http://medical-dictionary.thefreedictionary.com/insulin+resistance.
Rakugi H, Kamide K, Ogihara T. Vascular signaling pathways in the metabolic syndrome. Curr Hypertens Rep 2002;4:105-11.
Yuksel M, Yildiz A, Oylumlu M, Akyuz A, Aydin M, Kaya H, et al. The association between platelet/lymphocyte ratio and coronary artery disease severity. Anatol J Cardiol 2015; 15: 640-7. [CrossRef]
Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008; 102: 653-7. [CrossRef]
Uthamalingam S, Patvardhan EA, Subramanian S, Ahmed W, Martin W, Daley M, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol 2011; 107: 433-8. [CrossRef]
Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST elevation myocardial infarction. J Thromb Thrombolysis 2012; 34: 326-34. [CrossRef]
Demirtas L, Degirmenci H, Akbas EM, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int. J. Clin. Exp. Med. 2015;8: 11420–7.
Yilmaz H, Ucan B, Sayki M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab. Syndr. 2015;9: 299–304.
Manabe I: Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ J 2011;75: 2739-48.
Azab B, Zaher M, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, Gobunsuy R, Jadonath S, Baldari D, McCord D, Lafferty J: Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106:470-476.
Chua W, Charles KA, Baracos VE, Clarke SJ: Neutrophil/ lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer. Br J Cancer 2011;104:1288-95.
Onalan E, Gozel N, Donder E. Can hematological parameters in type 2 diabetes predict microvascular complication development?. Pak J Med Sci. 2019;35(6):1511-1515.
Bahadır A, Baltacı D, Y Türker, ve ark. Is the neutrophil to lymphocyte ratio indicative of inflammator state in patients with obesity and metabolic syndrome? Anatol J Cardiol 2015:15 (10):816-822. Doi:10.5152/akd.2014.5787.
Atmaca H.U, Akbaş F, Ökten İ.Ö, ve ark. Nötrofil lenfosit oranı obezlerde inflamatuar bir belirteç olarak kullanılabilir mi? İstanbul Med J:2014 15 (4) 35-42.
Brörntorp P. International Texbook of Obesity Türkçe, 1. Baskı, And Yayıncılık, İstanbul, 2002.
Kopelman PG. Hormones and obesity. Bailliere’s Clinical Endocrinology and metabolism 1994;8 (3):549-60.