The effect of insulin resistance on inflammation markers in individuals with obesity

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Hasan Atlı
Erhan Önalan
Burkay Yakar
Deccane Duzenci
Emir Dönder


Objective: Obesity has recently been recognized as a chronic low-grade inflammation condition. We aimed to compare the predictive values of insulin resistance and inflammatory indices in individuals with obesity.

Materials and Methods: 124 people who had a health check for obesity-related risk factors in our hospital between June 2018 and September 2019 were included in the study. Inflammatory markers of the patients were evaluated.

Results: The study group consists of a total of 224 people, and we compared the demographic data and laboratory parameters of the individuals. C-reactive protein (CRP) levels of obese individuals were statistically higher than those with normal body mass index (p <0.001). There was no statistically significant difference between the groups in terms of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values, among other inflammation markers. A positive and statistically significant correlation was found between body mass index and CRP level (r = 0.334, p <0.001). There was no significant correlation between body mass index and NLR and PLR.

Conclusion: As a result, CRP levels of obese individuals were statistically higher than individuals with normal body mass index. No statistically significant difference was found between the groups in terms of NLR and PLR values among other inflammation markers.


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Atlı, H., Önalan, E., Yakar, B. ., Duzenci, D., & Dönder, E. (2021). The effect of insulin resistance on inflammation markers in individuals with obesity. Medical Science and Discovery, 8(10), 619–622.
Research Article
Received 2021-10-12
Accepted 2021-10-17
Published 2021-10-18


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