Cognitive effects of COVID-19

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Ali Rıza Sonkaya
Büşra Sümeyye Polat
Bilgin Öztürk
Ülkühan Düzgün
Ömer Karadaş


Objective: Neurological involvement can be seen in Covid-19 and cognitive functions can be affected negatively. There is not enough study and data about cognitive functions of patients followed with Covid-19 diagnosis. For this reason, the current study aims to examine the cognitive functions of patients diagnosed with Covid-19.

Material and Methods: Patients, who were hospitalized and followed-up with the diagnosis of Covid-19, were selected as consecutive. For evaluating cognitive functions, Montreal Cognitive Assessment (MoCA) test was performed to under 65-year-old participants, Standardized Mini- Mental State Exam (MMSE) test was performed to 65-year-old and older participants and Hospital Anxiety and Depression Scale (HADS) was performed to all participants.

Results: The study has consisted of 32 patients and 35 volunteers. The mean of MMSE scores was found to be lower in the patient group than the control group (p>0.05). The mean of MoCA scores was found to be lower in the patient group than the control group, and it was statistically significant (p<0.05). Also, in the sub-group analyzes that assessed the attention of the MoCA test group, the patient group scores were lower than the control group and it was statistically significant (p<0.05). Hospital anxiety scale scores of the patient group were found to be significantly higher than the control group (p<0.05).

Conclusion: The result of this study is showed the presence of cognitive impairment and increased anxiety in patients with Covid-19 who had no previous cognitive deficit. Therefore, it is important to evaluate the patients with Covid-19 in terms of mood and cognition in detail.


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How to Cite
Sonkaya , A. R. ., Polat, B. S., Öztürk, B., Düzgün, Ülkühan, & Karadaş, Ömer. (2022). Cognitive effects of COVID-19. Medical Science and Discovery, 9(1), 61–65.
Research Article
Received 2022-01-09
Accepted 2022-01-17
Published 2022-01-24


Karadaş Ö, Öztürk B, Sonkaya AR. A prospective clinical study of detailed neurological manifestations in patients with COVID-19. Neurol Sci 2020; 41:1991-1995. DOI:

Su S, Wong G, Shi W, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol 2016; 24(6):490- 502. DOI:

Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet 2020; 395(10223):497-506. DOI:

Sonkaya AR, Öztürk B, Karadaş Ö. Cerebral hemodynamic alterations in patients with Covid-19. Turk J Med Sci. 2021 Apr 30;51(2):435-439. DOI:

Needham EJ, Chou SH-Y, Coles AJ, Menon DK. Neurological implications of COVID- 19 infections. Neurocrit Care 2020; 32:667–671. DOI:

Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GJ, van Goor, H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203(2):631-637. DOI:

Nasreddine Z, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005; 53:695-699. DOI:

Folstein MF, Folstein SE, McHugh PR. “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12(3):189-198. DOI:

Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67(6):361-370. DOI:

Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi 2002; 13(4):273-281.

Mao L, Wang M, Chen S, et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. MedRxiv.2020. DOI:

Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine 2020; 8(5): 475-481. DOI:

Bai Y, Yao L, Wei T, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA 2020; 323(14):1406-1407. DOI:

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020; 395(10223):507-513. DOI:

Li Y, Li M, Wang M, et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol 2020. DOI:

Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA neurology 2020; 77(6):683-690. DOI:

Asadi-Pooya AA, Simani L. Central nervous system manifestations of COVID-19: A systematic review. J Neurol Sci 2020; 6(15):413.116832. DOI:

Ahmad I, Rathore FA. Neurological manifestations and complications of COVID-19: A literature review. J Clin Neurosci 2020; 7(77):8-12. DOI:

Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS‐ CoV2 may play a role in the respiratory failure of COVID‐ 19 patients. J Med Virol 2020; 92(6):552-555. DOI:

Xiang YT, Yang Y, Li W, et al. Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed. The Lancet Psychiatry 2020; 7(3):228-229. DOI:

Wang C, Pan R, Wan X, et al. Immediate psychological responses and associated factors during the initial stage of the 2019 coronavirus disease (COVID-19) epidemic among the general population in China. Int J Environ Res Public Health 2020; 17(5):1729. DOI:

Özdin S, Bayrak Özdin Ş. Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender. Int J Soc Psychiatry 2020; 66(5):504–511. DOI:

Li S, Wang Y, Xue J, Zhao N, Zhu T. The impact of COVID-19 epidemic declaration on psychological consequences: a study on active Weibo users. Int J Environ Res Public Health 2020; 17(6):2032. DOI:

Speth MM, Singer-Cornelius T, Obere M, et al. Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics. Otolaryngology Head and Neck Surgery. 2020 Jul;163(1):114-120. DOI:

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