Serum 25-Hydroxyvitamin D level in Restless Legs Syndrome: A controlled study
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Abstract
Objective: We aimed to investigate 25-hydroxyvitamin D (25-OHD) level on a group of restless legs syndrome (RLS) patients.
Material and Methods: Twenty-one RLS patients and fourteen age and gender healthy controls (non RLS) with similar age and gender were included in the study. All patients underwent a physical examination for the neurologic and musculoskeletal system. The 25-OHD level was measured for all participants.
Results: The 25-hydroxyvitamin D levels were higher in the RLS patient group (20.06±8.79 ng/ml) than in the healthy control group (14.75±4.67 ng/ml). In the healthy control group ‘’without the RLS syndrome’’, 25-hydroxyvitamin D levels were below the normal range (<20 ng/ml). However, there were no statistical differences in terms of vitamin D level between the RLS and Control groups (p>0.05).
Conclusion: In this study, due to the absence of RLS syndrome in the control group despite low 25-hydroxyvitamin D levels (<20 ng/ml), a relationship could not be established between 25-hydroxyvitamin D levels and RLS syndrome. The cause of RLS syndrome does not seem to depend on a single parameter such as 25-OHD level.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Accepted 2022-01-24
Published 2022-01-26
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