The Evolution of Cholecystitis: A Global Productivity and Publication Trends: Bibliometric Analysis of Cholecystitis

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Murat Baki Yıldırım
Bulut özkan


Objective: There is still no bibliometric study on Cholecystitis, although the literature has an increasing number of global studies. This study aims to analyse the scientific articles published on Cholecystitis between 1980 and 2020 using statistical methods.

Material and Methods: Articles on Cholecystitis published between 1980 and 2020 were downloaded using the Web of Science (WoS) database and analysed using statistical and bibliometric methods.  Spearman correlation coefficient was used for correlation analyses. Non-linear (exponential model) regression analysis was used to predict the number of publications in the coming years. Keyword network visualisation maps were used to identify trend topics.

Results: A total of 5052 publications were found. 3174 (62.8%) of these publications, were articles. The top 2 countries that contributed most to the literature were the USA (788, 24.8%) and Japan (303, 9.5%). The most active top 3 institutions were Teikyo University (n=35), Washington University (35), and Seoul National University (27). The top 3 journals with the highest number of publications were Khirurgiya (n=124), American Surgeon (71), and Vestnik Khirurgii Imeni II Grekova (69). According to the average number of citations per article, the most influential journals were Annals of Surgery (Citation: 87), Radiology (61.6), and Journal of Hepato-Biliary-Pancreatic Surgery (56.9), respectively.

Conclusion: This comprehensive study on Cholecystitis, which has increased the number of articles in recent years, presented summary information of 3174 articles. Results can be said that the trend topics in cholecystitis studies in recent years are Tokyo guidelines, C-reactive protein, gallbladder drainage, emergency surgery, emergency cholecystectomy, cystic duct, choledocholithiasis, inflammation, acute cholecystitis, delayed laparoscopic cholecystectomy, and percutaneous transhepatic gallbladder drainage/aspiration. This article may be a useful resource for clinicians and scientists on global outputs of cholecystitis.


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How to Cite
Yıldırım, M. B., & özkan, B. . (2022). The Evolution of Cholecystitis: A Global Productivity and Publication Trends: Bibliometric Analysis of Cholecystitis. Medical Science and Discovery, 9(2), 80–89.
Research Article
Received 2022-02-07
Accepted 2022-02-18
Published 2022-02-19


Kimura Y, Takada T, Kawarada Y, et al. Definitions, pathophysiology, and epidemiology of acute cholangitis and Cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg. 2007;14(1):15-26. DOI:

Hirota, M., Takada, T., Kawarada, Y., Nimura, Y., Miura, F., Hirata, K., et al. (2007). Diagnostic criteria and severity assessment of acute Cholecystitis: Tokyo Guidelines. Journal of hepato-biliary-pancreatic surgery, 14(1), 78-82. DOI:

Takada T, Strasberg SM, Solomkin JS, Gomi H, Yoshida M, Mayumi T, et al. TG13: Updated Tokyo Guidelines for the management of acute cholangitis and Cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:1–7. DOI:

Yokoe, M., Takada, T., Strasberg, S. M., Solomkin, J. S., Mayumi, T., Gomi, H., et al. (2013). TG13 diagnostic criteria and severity grading of acute Cholecystitis (with videos). Journal of hepato-biliary-pancreatic sciences, 20(1), 35-46. DOI:

Yokoe, M., Hata, J., Takada, T., Strasberg, S. M., Asbun, H. J., Wakabayashi, G., et al. (2018). Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute Cholecystitis (with videos). Journal of Hepato‐biliary‐pancreatic Sciences, 25(1), 41-54. DOI:

Fuks D, Mouly C, Robert B, Hajji H, Yzet T, Regimbeau J-M. Acute Cholecystitis: preoperative CT can help the surgeon consider conversion from laparoscopic to open cholecystectomy. Radiology. 2012; 263: 128– 38. DOI:

Hafif A, Gutman M, Kaplan O, Winkler E, Rozin RR, Skornick Y. The management of acute Cholecystitis in elderly patients. Am Surg. 1991; 57(10):648-52.

Ransohoff DF, Miller GL, Forsythe SB, Hermann RE. Outcome of acute Cholecystitis in patients with diabetes mellitus. Ann Intern Med. 1987; 106(6):829-32. DOI:

Doğan, G., Karaca, O. A bibliometric analysis of the field of anesthesia during 2009–2018: A bibliometric analysis of anesthesia. Brazilian Journal of Anesthesiology. 2020:70 (2);140-152. DOI:

Doğan, G., İpek, H. (2020). The evolution of hypospadias publications: A bibliometric approach. Revista internacional de andrologia. DOI:

Muslu Ü, Demir E. Development of Rhinoplasty: Yesterday and Today. Medical Science 2019;23:294-301

Golpinar, M., Demir, E. (2020). Global research output of the cerebellum: Yesterday, today, and tomorrow. Journal of the Anatomical Society of India, 69(3), 155. DOI:

Yildirim, E., Demir, E. (2019). Comparative bibliometric analysis of fertility preservation. Annals of Medical Research, 26(8), 1622-8.

Demir, E., Akmeşe, Ö. F., Erbay, H., Taylan-Özkan, A., Mumcuoğlu, K. Y. (2020). Bibliometric analysis of publications on house dust mites during 1980–2018. Allergologia et immunopathologia, 48(4), 374-383. DOI:

Van Eck NJ. Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010;84(2):523–538. DOI:

The World Bank (2020). Website [accessed 1 Ekim 2020]

Lo CM, Liu CL, Fan ST, Lai EC, Wong J. Prospective srandomised study of early versus delayed laparoscopic cholecystectomy for acute Cholecystitis. Ann Surg. 1998;227(4):461-7. DOI:

P. B. S. Lai, K. H. Kwong, K. L. Leung et al., “Randomised trial of early versus delayed laparoscopic cholecystectomy for acute cholecystitis,” British Journal of Surgery, vol. 85, no. 6, pp. 764–767, 1998. DOI:

Kiviluoto T, Sirén J, Luukkonen P, Kivilaakso E. Randomised trial of laparoscopic versus open cholecystectomy for acute and gangrenous Cholecystitis. Lancet. 1998;351(9099):321-5. DOI:

Rattner DW, Ferguson C, Warshaw AL. Factors associated with successful laparoscopic cholecystectomy for acute Cholecystitis. Ann Surg. 1993;217(3):233-6. DOI:

Gurusamy K, Samraj K, Gluud C, Wilson E, Davidson BR. Meta-analysis of srandomised controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute Cholecystitis. Br J Surg. 2010;97(2):141-50. DOI:

Strasberg SM. Clinical practice. Acute calculous Cholecystitis. N Engl J Med. 2008;358(26):2804-11. DOI:

Fox, J. G., Dewhirst, F. E., Shen, Z., Feng, Y., Taylor, N. S., Paster, B. J., ... & Roa, I. (1998). Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic Cholecystitis. Gastroenterology, 114(4), 755-763. DOI:

Okamoto, K., Suzuki, K., Takada, T., Strasberg, S. M., Asbun, H. J., Endo, I., et al. (2018). Tokyo Guidelines 2018: flowchart for the management of acute Cholecystitis. Journal of Hepato‐biliary‐pancreatic Sciences, 25(1), 55-72. DOI:

Gutt, C. N., Encke, J., Köninger, J., Harnoss, J. C., Weigand, K., Kipfmüller, K., et al. (2013). Acute Cholecystitis: early versus delayed cholecystectomy, a multicenter srandomised trial (ACDC study, NCT00447304). Annals of surgery, 258(3), 385-393. DOI: