Non-Necrotizing Granulomas in Bone Marrow Biopsy of a Patient with Bicytopenia: Brucellosis Case Non-Necrotizing Granulomas

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Rafiye Ciftciler
Gulfidan Ozturk

Abstract

Objective: Brucellosis has the ability to mimic a variety of multisystem illnesses, exhibiting a wide range of clinical polymorphism that frequently leads to misdiagnosis and treatment delays, thus raising the risk of complications. In cases of brucellosis, hematologic abnormalities might manifest as anemia, leukopenia, thrombocytopenia, lymphomonocytosis, hemolytic anemia, disseminated intravascular coagulation, and pancytopenia.


Material and Methods: In this study, we presented the bone marrow biopsy findings of a brucellosis case.


Case: For ten days, a 19-year-old male patient with fever, exhaustion, weight loss, loss of appetite, and stomach pain was taken to the emergency room. A bone marrow aspiration and biopsy were conducted because of the patient's indications and symptoms. Brucella melitensis was isolated in the blood and bone marrow cultures on the 7th day.


Conclusion: Brucellosis, one of the most common zoonoses in the world and our country, can occur with a wide variety of complications.

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How to Cite
Ciftciler, R. ., & Ozturk, G. (2022). Non-Necrotizing Granulomas in Bone Marrow Biopsy of a Patient with Bicytopenia: Brucellosis Case: Non-Necrotizing Granulomas. Medical Science and Discovery, 9(4), 260–262. https://doi.org/10.36472/msd.v9i4.710
Section
Case Reports
Received 2022-03-30
Accepted 2022-04-17
Published 2022-04-29

References

Demir C, Karahocagil MK, Esen R, Atmaca M, Gönüllü H, Hayrettin A. Bone marrow biopsy findings in brucellosis patients with hematologic abnormalities. Chinese medical journal. 2012;125(11):1871-6.

Crosby E, Llosa L, Quesada MM, Carrillo P C, Gotuzzo E. Hematologic changes in brucellosis. Journal of Infectious Diseases. 1984;150(3):419-24.

Lowe CF, Showler AJ, Perera S, McIntyre S, Qureshi R, Patel SN, et al. Hospital-associated transmission of Brucella melitensis outside the laboratory. Emerging Infectious Diseases. 2015;21(1):150.

Al Dahouk S, Nöckler K. Implications of laboratory diagnosis on brucellosis therapy. Expert review of anti-infective therapy. 2011;9(7):833-45.

Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. Clinical manifestations of human brucellosis: a systematic review and meta-analysis. PLoS neglected tropical diseases. 2012;6(12):e1929.

Citak EC, Citak FE, Tanyeri B, Arman D. Hematologic manifestations of brucellosis in children: 5 years experience of an anatolian center. Journal of Pediatric Hematology/Oncology. 2010;32(2):137-40.

Yildirmak Y, Palanduz A, Telhan L, Arapoglu M, Kayaalp N. Bone marrow hypoplasia during Brucella infection. Journal of pediatric hematology/oncology. 2003;25(1):63-4.

Akbayram S, Dogan M, Akgun C, Peker E, Parlak M, Caksen H, et al. An analysis of children with brucellosis associated with pancytopenia. Pediatric Hematology and Oncology. 2011;28(3):203-8.

Erduran E, Makuloglu M, Mutlu M. A rare hematological manifestation of brucellosis: reactive hemophagocytic syndrome. Journal of Microbiology, Immunology and Infection. 2010;43(2):159-62.

Al-Eissa YA, Assuhaimi SA, Al-Fawaz IM, Higgy KE, Al-Nasser MN, Al-Mobaireek KF. Pancytopenia in children with brucellosis: clinical manifestations and bone marrow findings. Acta haematologica. 1993;89(3):132-6.

Kvasnicka H, Thiele J. Differentiation of granulomatous lesions in the bone marrow. Der Pathologe. 2002;23(6):465-71.

Kitt E, Brannock KR, VonHolz LA, Planet PJ, Graf E, Pillai V, editors. A case report of pediatric brucellosis in an Algerian immigrant. Open forum infectious diseases; 2017: Oxford University Press.

Young EJ, Tarry A, Genta RM, Ayden N, Gotuzzo E. Thrombocytopenic purpura associated with brucellosis: report of 2 cases and literature review. Clinical infectious diseases. 2000;31(4):904-9.