Prognostic values of LDH and Hematological factors in Patients with Sudden Hearing Loss LDH and Hematological Factors In Sudden Hearing Loss

Main Article Content

Serkan Dedeoğlu
Muhammed Ayral
Serdar Ferit Toprak


Objective: In our study, we aimed to evaluate the relationship between Lactate Dehydrogenase and hematological parameters, neutrophil, Neutrophil lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume serum levels in patients with Sudden sensorineural hearing loss prognosis.

Methods: 60 patients were hospitalized and treated for Sudden Hearing Loss at Dicle University Hospital Ear Nose Throat Clinic between May 2013 and April 2020, and 60 healthy individuals without any health problems were included in the study. Pretreatment peripheral blood was drawn from all subjects, followed by routine blood cell analysis. The absolute numbers of neutrophils, lymphocytes, and platelets in peripheral blood were obtained, and the Neutrophil lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume of each case were calculated.

Results: A total of 120 participants, including 60 Sudden sensorineural hearing loss patients case group and 60 healthy individuals in the control group, were included in the study. The median age of the case group was 46.0 (29.0-55.0), and the control group was 48.0 (33.5-58.5), and no statistically significant difference was found between the groups in terms of age (p = 0.191). The median Lactate Dehydrogenase, Neutrophil, and Neutrophil lymphocyte ratio of the case group was significantly higher than the control group (p <0.05). There was no significant difference between the groups in terms of thrombocyte, mean platelet volume, lymphocyte, platelet lymphocyte ratio, body mass index, and gender (p> 0.05).

Conclusion: We think that the increase in Lactate Dehydrogenase level may be a poor prognostic factor in patients with sudden hearing loss that does not improve. In addition, we believe that the increase in neutrophil count and Neutrophil lymphocyte ratio is quite significant but cannot be considered a poor prognostic factor.


Download data is not yet available.

Article Details

How to Cite
Dedeoğlu, S., Ayral, M., & Toprak, S. F. (2022). Prognostic values of LDH and Hematological factors in Patients with Sudden Hearing Loss: LDH and Hematological Factors In Sudden Hearing Loss. Medical Science and Discovery, 9(6), 340–346.
Research Article
Received 2022-05-26
Accepted 2022-06-08
Published 2022-06-11


Wilson YL, Gandolfi MM, Ahn IE, Yu G, Huang TC, Kim AH. Cost analysis of asymmetric sensorineural hearing loss investigations. Laryngoscope. 2010;120(9):1832-6. DOI:

Alexander TH, Harris JP. Incidence of sudden sensorineural hearing loss. Otol Neurotol. 2013;34(9):1586-9. DOI:

Rauch SD. Clinical practice. Idiopathic sudden sensorineural hearing loss. N Engl J Med. 2008;359(8):833-40. DOI:

Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120(5):1011-21. DOI:

Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K, et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. Journal of Neurogenetics. 2012;26(3-4):387-96. DOI:

Chen L, Zhang G, Zhang Z, Wang Y, Hu L, Wu J. Neutrophil-to-lymphocyte ratio predicts diagnosis and prognosis of idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis. Medicine (Baltimore). 2018;97(38):e12492. DOI:

Nash SD, Cruickshanks KJ, Zhan W, Tsai MY, Klein R, Chappell R, et al. Long-term assessment of systemic inflammation and the cumulative incidence of age-related hearing impairment in the epidemiology of hearing loss study. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2014;69(2):207-14. DOI:

Qiao X-F, Li X, Wang G-P, Bai Y-H, Zheng W, Li T-L. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with sudden sensorineural hearing loss. Medical principles and practice. 2019;28(1):23-7. DOI:

Bulğurcu S, Dikilitaş B, Arslan İB, Çukurova İ. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in pediatric patients with idiopathic sudden hearing loss. The journal of international advanced otology. 2017;13(2):217. DOI:

Ede LC, O’Brien J, Chonmaitree T, Han Y, Patel JA. Lactate dehydrogenase as a marker of nasopharyngeal inflammatory injury during viral upper respiratory infection: implications for acute otitis media. J Pediatric research. 2013;73(3):349-54. DOI:

Buyukkaya E, Karakas MF, Karakas E, Akcay AB, Tanboga IH, Kurt M, et al. Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome. Clin Appl Thromb Hemost. 2014;20(2):159-63. DOI:

Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. J International archives of medicine. 2012;5(1):1-6. DOI:

Hamminga EA, van der Lely AJ, Neumann HA, Thio HB. Chronic inflammation in psoriasis and obesity: implications for therapy. Med Hypotheses. 2006;67(4):768-73. DOI:

Turkmen K, Erdur FM, Ozcicek F, Ozcicek A, Akbas EM, Ozbicer A, et al. Platelet‐to‐lymphocyte ratio better predicts inflammation than neutrophil‐to‐lymphocyte ratio in end‐stage renal disease patients. J Hemodialysis International. 2013;17(3):391-6. DOI:

Aktas G, Duman T, Atak B, Kurtkulagi O, Bilgin S, Basaran E, et al. Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters. Family Medicine & Primary Care Review. 2020;22(2):107-10. DOI:

Bilgin S, Aktas G, Zahid Kocak M, Atak BM, Kurtkulagi O, Duman TT, et al. Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men. The Aging Male. 2020;23(5):923-7. DOI:

Aktas G, Sit M, Dikbas O, Erkol H, Altinordu R, Erkus E, et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis. Revista da Associação Médica Brasileira. 2017;63:1065-8. DOI:

Sit M, Aktas G, Erkol H, Yaman S, Keyif F, Savli H. Neutrophil to lymphocyte ratio is useful in differentiation of malign and benign thyroid nodules. Puerto Rico health sciences journal. 2019;38(1):60-3.

Atak B, Aktas G, Duman TT, Erkus E, Kocak MZ, Savli H. Diabetes control could through platelet-to-lymphocyte ratio in hemograms. Revista da Associação Médica Brasileira. 2019;65:38-42. DOI:

Afsin H, Aktas G. Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios are useful in differentiation of thyroid conditions with normal and increased uptake. The Ethiopian Journal of Health Development. 2021;35(3).

Atak BM, Kahveci GB, Bilgin S, Kurtkulagi O, Kosekli MA. Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules. Experimental Biomedical Research. 2021;4(2):148-53. DOI:

Kosekli MA. Mean platelet volume and platelet to lymphocyte count ratio are associated with hepatitis B-related liver fibrosis. European Journal of Gastroenterology & Hepatology. 2022;34(3):324-7. DOI:

Aktas G, Kocak MZ, Duman TT, Erkus E, Atak BM, Sit M, et al. Mean Platelet Volume (MPV) as an inflammatory marker in type 2 diabetes mellitus and obesity. Bali Med J. 2018;7(3):650-3. DOI:

Duman TT, Aktas G, Atak B, Kocak MZ. Is mean platelet volume to platelet ratio a promising indicator of diabetic regulation in type 2 diabetes mellitus. J Med Res. 2018;4(3):137-9. DOI:

Cakır L, Aktas G, Mercimek OB, Enginyurt O, Kaya Y, Mercimek K. Are red cell distribution width and mean platelet volume associated with rheumatoid arthritis. Biomed Res. 2016;27(2):292-4.

Aktaş G, Sit M, Tekçe H, Alçelik A, Savli H, Simsek T, et al. Mean platelet volume in nasal polyps. West Indian Med J. 2013;62(6):515-5188. DOI:

Wilson WR, Byl FM, Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol. 1980;106(12):772-6. DOI:

Siegel LG. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am. 1975;8(2):467-73. DOI:

Lazarini PR, Camargo AC. Idiopathic sudden sensorineural hearing loss: etiopathogenic aspects. Braz J Otorhinolaryngol. 2006;72(4):554-61. DOI:

Stokroos RJ, Albers FW, Schirm J. The etiology of idiopathic sudden sensorineural hearing loss. Experimental herpes simplex virus infection of the inner ear. Am J Otol. 1998;19(4):447-52.

Chen X, Fu YY, Zhang TY. Role of viral infection in sudden hearing loss. J Int Med Res. 2019;47(7):2865-72. DOI:

Cvorovic L, Deric D, Probst R, Hegemann S. Prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2008;29(4):464-9. DOI:

Zhu WY, Jin X, Ma YC, Liu ZB. MIF protects against oxygen-glucose deprivation-induced ototoxicity in HEI-OC1 cochlear cells by enhancement of Akt-Nrf2-HO-1 pathway. Biochem Biophys Res Commun. 2018;503(2):665-70. DOI:

Baklacı D, Guler İ, Kuzucu İ, Kum RO, Özcan M. Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy. J Cureus. 2020;12(3). DOI:

Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807. DOI:

Cao Z, Li Z, Xiang H, Huang S, Gao J, Zhan X, et al. Prognostic role of haematological indices in sudden sensorineural hearing loss: Review and meta-analysis. Clin Chim Acta. 2018;483:104-11. DOI:

Durmus K, Terzi H, Karatas TD, Dogan M, Uysal IO, Sencan M, et al. Assessment of Hematological Factors Involved in Development and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss. J Craniofac Surg. 2016;27(1):e85-91. DOI:

Ha R, Lim BW, Kim DH, Park JW, Cho CH, Lee JH. Predictive values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and other prognostic factors in pediatric idiopathic sudden sensorineural hearing loss. International Journal of Pediatric Otorhinolaryngology. 2019;120:134-9. DOI:

İkincioğulları A, Köseoğlu S, Kılıç M, Atan D, Özcan KM, Çetin MA, et al. New inflammation parameters in sudden sensorineural hearing loss: neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Int Adv Otol. 2014;10(3):197-200. DOI:

Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest. 2005;115(12):3378-84. DOI:

Ulu S, Ulu MS, Ahsen A, Yucedag F, Aycicek A, Celik S. Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss. Eur Arch Otorhinolaryngol. 2013;270(11):2875-8. DOI:

Sagit M, Kavugudurmaz M, Guler S, Somdas MA. Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss. J Laryngol Otol. 2013;127(10):972-6. DOI:

Karli R, Alacam H, Unal R, Kucuk H, Aksoy A, Ayhan E. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? J Indian Journal of Otolaryngology Head Neck Surgery. 2013;65(4):350-3. DOI: