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Objective: The COVID-19 disease, which first appeared in Wuhan, China, at the end of 2019, soon affected the whole world. This study aims to examine the relationship between the demographic characteristics and clinical symptoms of COVID-19 patients and mortality rates during the COVID-19 pandemic period.
Material and Methods: This retrospective observational study was done on the files of 671 dead or living patients with laboratory-confirmed COVID-19 pneumonia hospitalized in Sinop State Hospital in Turkey from February to September of 2020. The demographic features such as sex, age, and comorbidities such as diabetes, hypertension, etc., and clinical symptoms of the disease such as fever, cough, shortness of breath, respiratory distress, weakness, head rotation, etc., were recorded.
Results: The total mean age of the patients was 56.08 years. The most common symptoms were cough, fever, respiratory distress, shortness of breath, and the most common comorbidities were hypertension, diabetes, ischemic heart disease, and COPD. There was a statistically significant difference between the dead and living patients in terms of sex (p=0.011, EXP(B)=0.429), cough (p=0.000, EXP(B)=0.137), and respiratory illness (p=0.000, EXP(B)= 15.526). There was a statistically significant difference between the dead and living patients in terms of age, number of additional illness, number of arrival complaint, length of stay in the hospital, intensive care hospitalization period, and number of medications used (p-values=0.000, 0.040, 0.000, 0.020, 0.030, and 0.000, respectively).
Conclusion: As a result of our study, gender, cough, and respiratory tract disease were statistically effective factors for course of illness. In addition, there was a significant difference between living and deceased patients in terms of age, number of additional diseases, number of admission complaints, length of hospital stay, length of stay in the intensive care unit, and number of drugs used. According to these results, it has been concluded that COVID-19 patients with these factors should be followed more carefully.
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Yang X, Yu Y, Xu J, Shu H, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. 2020 May 1;8(5):475-81. DOI: https://doi.org/10.1016/S2213-2600(20)30079-5
WHO. Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: interim guidance. January 11, 2020. https://apps.who.int/iris/handle/10665/330893 Date of Access: November 7, 2021.
Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, Duan G. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020 Mar 27;12(4):372. DOI: https://doi.org/10.3390/v12040372
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet. 2020 Feb 15;395(10223):497-506. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5
Goshayeshi L, Akbari Rad M, Bergquist R, Allahyari A, Hashemzadeh K, Hoseini B. Demographic and clinical characteristics of severe Covid-19 infections: a cross-sectional study from Mashhad University of Medical Sciences, Iran. BMC infectious diseases. 2021 Dec;21(1):1-8. DOI: https://doi.org/10.1101/2020.05.20.20108068
Drosten C, Günther S, Preiser W, Van Der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. New England journal of medicine. 2003 May 15;348(20):1967-76. DOI: https://doi.org/10.1056/NEJMoa030747
Gürbüz T, Gökmen O, Kaptan G, İNANLI E, Karadeniz SB, SÖYLEMEZ NE, Söylemez İ. Investigating anxiety, depression and obsessive-compulsive disorders among the pregnant women during Covid-19 pandemic. Journal of Health Sciences and Medicine. 2021;4(1):7-12. DOI: https://doi.org/10.32322/jhsm.769006
Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R, Iotti G. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. Jama. 2020 Apr 28;323(16):1574-81. DOI: https://doi.org/10.1001/jama.2020.5394
Roncon L, Zuin M, Rigatelli G, Zuliani G. Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome. Journal of Clinical Virology. 2020 Jun 1;127:104354. DOI: https://doi.org/10.1016/j.jcv.2020.104354
Halvatsiotis P, Kotanidou A, Tzannis K, Jahaj E, Magira E, Theodorakopoulou M, Konstandopoulou G, Gkeka E, Pourzitaki C, Kapravelos N, Papoti S. Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity. Diabetes research and clinical practice. 2020 Aug 1;166:108331. DOI: https://doi.org/10.1016/j.diabres.2020.108331
Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI, Lloyd-Smith JO. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. New England journal of medicine. 2020 Apr 16;382(16):1564-7. DOI: https://doi.org/10.1056/NEJMc2004973
Altintas M, Akdeniz G, Gurbuz B, Kara Y, Celbis O. Demographic and clinical features of COVID-19 cases in Serik, Turkey. Medicine. 2020;9(3):657-1. DOI: https://doi.org/10.5455/medscience.2020.07.124
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. Jama. 2020 Mar 17;323(11):1061-9. DOI: https://doi.org/10.1001/jama.2020.1585
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The lancet. 2020 Mar 28;395(10229):1054-62. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Report of the WHO-China joint mission on Coronavirus disease 2019 (COVID-19) WHO, 2020. (https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf. Date of Access: November 7, 2021.)
Suleyman G, Fadel RA, Malette KM, Hammond C, Abdulla H, Entz A, Demertzis Z, Hanna Z, Failla A, Dagher C, Chaudhry Z. Clinical characteristics and morbidity associated with coronavirus disease 2019 in a series of patients in metropolitan Detroit. JAMA network open. 2020 Jun 1;3(6):e2012270-. DOI: https://doi.org/10.1001/jamanetworkopen.2020.12270
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, Barnaby DP, Becker LB, Chelico JD, Cohen SL, Cookingham J. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. Jama. 2020 May 26;323(20):2052-9. DOI: https://doi.org/10.1001/jama.2020.6775
Garg S, Kim L, Whitaker M, O’Halloran A, Cummings C, Holstein R, Prill M, Chai SJ, Kirley PD, Alden NB, Kawasaki B. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019—COVID-NET, 14 States, March 1–30, 2020. Morbidity and mortality weekly report. 2020 Apr 17;69(15):458. DOI: https://doi.org/10.15585/mmwr.mm6915e3
Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, Alvarado-Arnez LE, Bonilla-Aldana DK, Franco-Paredes C, Henao-Martinez AF, Paniz-Mondolfi A. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel medicine and infectious disease. 2020 Mar 1;34:101623. DOI: https://doi.org/10.1016/j.tmaid.2020.101623
Guan WJ, Ni ZY, Hu Y. Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JJ, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Cheng Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS. Clinical characteristics of 2019 novel coronavirus infection in China. N Engl J Med. 2020. DOI: https://doi.org/10.1056/NEJMoa2002032
Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, Cuomo-Dannenburg G, Thompson H, Walker PG, Fu H, Dighe A. Estimates of the severity of coronavirus disease 2019: a model-based analysis. The Lancet infectious diseases. 2020 Jun 1;20(6):669-77. DOI: https://doi.org/10.1016/S1473-3099(20)30243-7
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. jama. 2020 Apr 7;323(13):1239-42. DOI: https://doi.org/10.1001/jama.2020.2648
Aggarwal S, Garcia-Telles N, Aggarwal G, Lavie C, Lippi G, Henry BM. Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): Early report from the United States. Diagnosis. 2020 May 26;7(2):91-6. DOI: https://doi.org/10.1515/dx-2020-0046
Lei S, Jiang F, Su W, Chen C, Chen J, Mei W, Zhan LY, Jia Y, Zhang L, Liu D, Xia ZY. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection. EClinicalMedicine. 2020 Apr 1;21:100331. DOI: https://doi.org/10.1016/j.eclinm.2020.100331
Cheng ZJ, Shan J. 2019 Novel coronavirus: where we are and what we know. Infection. 2020 Apr;48(2):155-63. DOI: https://doi.org/10.1007/s15010-020-01401-y