Does Chronic Immune Thrombocytopenia Lead to Hearing Loss?

Main Article Content

Melis Demirag Evman
Esra Turan Erkek

Abstract

Objective: We aimed to investigate the incidence of hearing loss in patients followed up for Chronic Immune Thrombocytopenia Purpura (ITP).


Material and Methods: All patients over the age of 18 who referred to the hematology outpatient clinic between January and June 2020 and followed up with the diagnosis of Chronic ITP were included in the study. Hearing tests of patients diagnosed with Chronic ITP and received first-line treatment (IVIG and corticosteroid) for any reason other than ear diseases during their treatment were evaluated retrospectively. Patients with a history of hearing loss, perforation of the tympanic membrane or who had any squeal due to a previous chronic ear infection and patients who had a previous ear operation were excluded from the study. In addition, patients' age, gender, time of ITP diagnosis, platelet values at the time of diagnosis, platelet values during audiological evaluation, concomitant disease, history of splenectomy, additional drug use and ISTH-SSC Bleeding Evaluation Score data were also recorded.


Results: Of the 34 cases, 58.8% (n=20) were female and 41.2% (n=14) were male. The mean age was 49.06±18.26. Similarly, when compared, usage of IVIG/Methylprednisolone,  IVIG/ Methylprednisolone /Eltrombopag, and IVIG/Methylprednisolone /Rituximab/Eltrombopag was not found to be a factor that would cause hearing loss (p>0.05). No statistical correlation was found between ISTH-SSC and time of diagnosis (months) and hearing loss (p>0.05).


Conclusion: Parameters such as various drugs used in the course of Chronic ITP disease, age, gender, time of diagnosis, and presence of concomitant disease do not cause hearing loss.

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Article Details

How to Cite
Demirag Evman, M., & Turan Erkek, E. (2022). Does Chronic Immune Thrombocytopenia Lead to Hearing Loss?. Medical Science and Discovery, 9(10), 577–580. https://doi.org/10.36472/msd.v9i10.819
Section
Research Article
Received 2022-09-30
Accepted 2022-10-21
Published 2022-10-22

References

Kucukkaya RD. Kanama ve Pıhtılasma Bozukluklari, Ic Hastaliklari Dergisi. 2010; 17: 33-43

Neunert C, Terrell DR, Arnold DM, Buchanan G, Cines DB, Cooper N, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019 Dec 10;3(23):3829-3866.

Cooper N, Ghanima W. Immune Thrombocytopenia. N Engl J Med. 2019;381(10):945-955.

Kohli R, Chaturvedi S. Epidemiology and Clinical Manifestations of Immune Thrombocytopenia. Hamostaseologie. 2019 Aug;39(3):238-249.

Koylu A, Pamuk GE, Uyanik MS, Demir M, Pamuk ON. Immune thrombocytopenia: epidemiological and clinical features of 216 patients in northwestern Turkey. Ann Hematol. 2015;94(3):459-66.

Cines DB, Cuker A, Semple JW. Pathogenesis of immunethrombocytopenia. Presse Med 2014;43(4 Pt 2):e49–59.

Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H. Idiopathic thrombocytopenic purpura (ITP) - new era for an old disease. Rom J Intern Med. 2019 Dec 1;57(4):273-283.

Moulis G, Germain J, Comont T, Brun N, Dingremont C, Castel B, et al. Investigators Group. Newly diagnosed immune thrombocytopenia adults: Clinical epidemiology, exposure to treatments, and evolution. Results of the CARMEN multicenter prospective cohort. Am J Hematol. 2017 Jun;92(6):493-500.

Rodeghiero F. ITP and thrombosis: an intriguing association. Blood Adv. 2017 Nov 14;1(24):2280.

Cunningham LL, Tucci DL. Hearing Loss in Adults. N Engl J Med. 2017; 21;377(25):2465-2473.

Salomone R, Abu TAA, Chaves AG, Bocalini MCC, de Oliveira Vicente A, Riskalla PE. Sudden hearing loss caused by labyrinthine hemorrhage. Braz J Otorhinolaryngol. 2008;74(5):776-779.

Meunier A, Clavel P, Aubry K, Lerat J. A sudden bilateral hearing loss caused by inner ear hemorrhage. Eur Ann Otorhinolaryngol Head Neck Dis. 2020;137(1):65-67.

Roland PS. New Developments in our Understanding of Ototoxicity. Ear, Nose & Throat Journal. 2004;83(9_suppl_4):15-17.

Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120(5):1011-21.

Mierzwa K, Schneider G, Müller A. Sudden sensorineural hearing loss during oral anticoagulant therapy. J Laryngol Otol. 2004;118(11):872-6.

Chen XH, Zeng CJ, Fang ZM, Zhang R, Cheng JM, Lin C. The Natural History of Labyrinthine Hemorrhage in Patients With Sudden Sensorineural Hearing Loss. Ear Nose Throat J. 2019;98(5):E13-E20.

Chern A, Famuyide AO, Moonis G, Lalwani AK. Bilateral Sudden Sensorineural Hearing Loss and Intralabyrinthine Hemorrhage in a Patient With COVID-19. Otol Neurotol. 2021;42(1):e10-e14.

Vakkalanka S, Ey E, Goldenberg RA. Inner ear hemorrhage and sudden sensorineural hearing loss. Am J Otol. 2000;21(5):764-5.

Ito S, Fujiwara SI, Ikeda T, Toda Y, Mashima K, Umino K, et al. Evaluation of thrombotic events in patients with immune thrombocytopenia. Ann Hematol. 2020;99(1):49-55.

Orsoni JG, Laganà B, Rubino P, Zavota L, Bacciu S, Mora P. Rituximab ameliorated severe hearing loss in Cogan's syndrome: a case report. Orphanet J Rare Dis. 2010; 16;5:18.

Aydogdu I, Ozturan O, Kuku I, Kaya E, Sevinc A, Yildiz R. Bilateral Transient Hearing Loss Associated with Vincristine Therapy: Case Report, Journal of Chemotherapy. 2000;12;6:530-532.

Rodeghiero F, Tosetto A, Abshire T, Arnold DM, Coller B, James P, et al. ISTH/SSC joint VWF and Perinatal/Pediatric Hemostasis Subcommittees Working Group. ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders. J Thromb Haemost. 2010;8(9):2063-5.