Relationship between vitamin D levels and hematological parameters Vitamin D levels and hematological parameters
Article Sidebar
Main Article Content
Abstract
Objective: This study aims to examine the relationship between serum vitamin D levels and hematological parameters, and body mass index.
Material and Methods: It was carried out in the internal medicine outpatient clinic of Ayancık State Hospital between April 2017 and November 2020. Information about the sociodemographic and laboratory values of the patients was obtained from the hospital information system. The patients were divided into two groups as those with vitamin D levels below 20 ng/ml and those with over 30 ng/ml. Vitamin D levels and hematological parameters of all patients were examined.
Results: Of the 343 patients included in the study, 277 were women. When vitamin D levels were evaluated, vitamin D levels were significantly lower in women (82.7%; n:244) according to gender (p=0.023). When vitamin D levels are assessed according to age, It was observed that the vitamin D level of the patients included in the study, especially in the advanced age group, was low. There was no significant difference between vitamin D levels and body mass index (p=0.138). Age, MCV, MPV, HDL, Calcium (Ca), Phosphorus, Vitamin B-12, Vitamin D levels were found to be significantly higher in female patients with adequate vitamin D levels (p<0.05).
Conclusion: In our study, it was observed that there was a significant relationship between vitamin D levels, age, gender, platelet level, monocyte, MCV, neutrophil, protein, HDL, calcium, and vitamin B12 levels. Beside the treatment and clinical examinations, it is necessary to monitor and evaluate the vitamin D levels of the patients, as well as hematological, biochemical and endocrinological parameter changes.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Accepted 2023-01-14
Published 2023-01-21
References
Türkiye Endokrinoloji ve Metabolizma Derneği. Osteoporoz Ve Metabolik Kemik Hastalıkları Tanı Ve Tedavi Kılavuzu 2018: 119-27.
Chambe P, Harvey D, Ferrier D. Biyokimya lippincott’s ıllustrated reviews 3. baskı. İstanbul, Nobel Tıp Kitapevi. 2007:384-7
Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiological reviews. 1998;78(4):1193-231.
Bringhurst FR. Bone and mineral metabolism in health and disease. Harrison's principles of internal medicine. 2008:2365-77.
Lim S, Kim MJ, Choi CS et al. Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects. Am J Clin Nutr 2013;97(3):524-530
Lim S, Shin H, Kim MJ et al. Vitamin D in adequacy is associated with significant coronary artery stenosis in a communitybased elderly cohort: the Korean Longitudinal Study on Health and Aging. J Clin Endocrinol Metab 2012;97(1):169-178.
Alagöl F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, Sandalci O. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 2000;23(3):173-7.
Holick MF. Vitamin D: a D-Lightful health perspective. Nutrition reviews. 2008;66(suppl_2):S182-S94.
Hyppönen E, Boucher BJ, Berry DJ, Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes. 2008;57(2):298-305.
Hutchinson MS, Figenschau Y, Almås B et al. Serum 25- hydroxyvitamin D levels in subjects with reduced glucose tolerance and type 2 diabetes - the Tromsø OGTT-study. Int J Vitam Nutr Res. 2011; 81 (5): 317-27. doi: 10.1024/0300- 9831/a000079.
Cumhur Cure M, Cure E, Yuce S et al. Mean platelet volume and vitamin D level. Ann Lab Med 2014; 34:98-103.
Hossein-nezhad A, Holick MF. Vitamin D for health: A Global perspective. Mayo Clin Proc 2013 July; 88(7):720–55. doi:10.1016/j.mayocp.2013.05.011.
Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 2011; 31(1):48-54.
Linnebur SA, Vondracek SF, Griend JPV et al. Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado. The American journal of geriatric pharmacotherapy. 2007;5(1):1-8.
Heidari B, Haji Mirghassemi MB. Seasonal variations in serum vitamin D according to age and sex. Caspian J Intern Med 2012;3:535-540.
Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 2006;92:39-48.) (Rostand SG. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension 1997;30:150-6.
Özkan B, Döneray H. D vitamininin iskelet sistemi dışı etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi 2011;54:99-119.
Oudshoorn C, Mattace-Raso FU, van der Velde N et al. Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with alzheimer’s disease. Dement Geriatr Cogn Disord 2008;25:539-43.
Osborne JE, Hutchinson PE. Vitamin D and systemic cancer: Is this relevant to malignant melanoma? Br J Dermatol 2002;147:197-213.
Dini C, Bianchi A. The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases. Ann Ist Super Sanita 2012;48:319-27.
Dıx Cf, Barcley Jl, Wrıght Orl (2018). The role of vitamin D in adipogenesis. Nutrition Reviews, 76(1):47-59.
Earthman Cp, Beckman Lm, Masodakıkaar K et al. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. International Journal of Obesity, 2012;36(3): 387-396.
Palacios C, Gil K, Pérez CM et al. Determinants of vitamin D status among overweight and obese Puerto Rican adults. Ann Nutr Metab. 2012;60(1):35-43.
Adorini L. 1, 25-Dihydroxyvitamin D3 analogs as potential therapies in transplantation. Current opinion in investigational drugs (London, England: 2000). 2002;3(10):1458-63.
Blazsek I, Farabos C, Quittet P et al. Bone marrow stromal cell defects and 1 alpha, 25-dihydroxyvitamin D3 deficiency underlying human myeloid leukemias. Cancer detection and prevention. 1996;20(1):31-42.
Amer M, Qayyum R. Relation between serum 25- hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006.
Hyppönen E, Berry D, Cortina-Borja M, et al. 25- Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort. PLoS One. 2010;5:e10801.
Christodoulidis G, Vittorio TJ, Fudim M et al. Inflammation in coronary artery disease. Cardiol Rev 2014; 22:279-88;
Taniguchi K, Karin M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol 2014; 26:54-74; PMID:24552665; http://dx.doi.org/10.1016/j.smim.2014.01.001
van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005;97(1–2):93–101.
Guillot X, Semerano L, Saidenberg-Kermanac’h N et al. Vitamin D and inflammation. Joint Bone Spine, 2010; 77:552–557.
Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805–12.
Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-161.
Akbas EM, Gungor A, Ozcicek A et al. Vitamin D and inflammation: evaluation with neutrophil-to lymphocyte ratio and platelet-to-lymphocyte ratio. Arch Med Sci. 2016 Aug 1;12(4):721-7
Ngo DT, Sverdlov AL, McNeil JJ et al. Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations? Am J Med. 2010;123:335–41.
Ashraf AP, Fisher G, Alvarez J et al. Associations of C-reactive protein to indices of vascular health and the influence of serum 25(OH)D status in healthy adults. J Nutr Metab. 2012;2012:475975.
Chitalia N, Ismail T, Tooth L et al. Impact of vitamin D supplementation on arterial vasomotion, stiffness and endothelial biomarkers in chronic kidney disease patients. PLoS One. 2014;9:e91363.
Bednarek-Skublewska A, Smolen A, Jaroszynski A et al. Effects of vitamin D3 on selected biochemical parameters of nutritional status, inflammation, and cardiovascular disease in patients undergoing long-term hemodialysis. Pol Arch Med Wewn. 2010;120:167–74.
Sunbul M, Gerin F, Durmus E et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens. 2014;36:217–21.
Bednarek-Skublewska A, Smolen A, Jaroszynski A et al. Effects of vitamin D3 on selected biochemical parameters of nutritional status, inflammation, and cardiovascular disease in patients undergoing long-term hemodialysis. Pol Arch Med Wewn. 2010;120:167–74.
Jameson JL, Weetman AP. Tiroid bezi hastalıkları. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison İç Hastalıkları Prensipleri. 15 ed. İstanbul; Çeviri editörü: Sağlıker Y: Nobel Matbaacılık. 2004. p.2060-75.
Ersöz B. Kalsiyum ve fosfor metabolizmasını düzenleyen hormonlar. In: Onat T, Emerk K, Sözmen EY. İnsan Biyokimyası. Ankara; 2002. p.467-72.
Roger B. D vitamini: From photosynthesisi, metabolism, and action to clinical applications. Endocrinology 5rd edition; Philadelphia Elsevier Saunders, 2003; 1435-64.