Neuroendocrine Carcinoma of the Breast: Report of A Case

Main Article Content

Mehmet Sait Ozsoy
Hakan Baysal
Fatih Buyuker
Begumhan Baysal
Gozde Kir
Orhan Alimoglu


Objective: Breast cancer is the most prevalent malignant disease among women and ranks among the top three most common cancers globally, alongside lung and colon cancer. Various subtypes of breast cancer have been identified. Primary neuroendocrine breast cancer, a rare and distinct type of breast carcinoma, lacks specific radiological findings. The definitive diagnosis is achieved through the expression of Synaptophysin and Chromogranin A on tumor biopsy, and it necessitates the absence of tumor detection in other regions. Staging and treatment are recommended to follow a similar approach as that of conventional breast cancer. It is believed that the prognosis of neuroendocrine breast tumors is generally poorer compared to invasive cancers.


Download data is not yet available.

Article Details

How to Cite
Ozsoy, M. S., Baysal, H. ., Buyuker, F. ., Baysal, B. ., Kir, G. ., & Alimoglu, O. . (2023). Neuroendocrine Carcinoma of the Breast: Report of A Case. Medical Science and Discovery, 10(5), 357–360.
Case Reports
Received 2023-05-15
Accepted 2023-05-26
Published 2023-05-27


Harbeck N, Gnant M. Breast cancer. Lancet. 2017; 389(10074) :1134–1150.

Lee DH, Park AY, Seo BK, Kim YS, Lee KY, Cha SH. Primary Neuroendocrine Carcinoma of the Breast with Clinical Features of Inflammatory Breast Carcinoma: A Case Report and Literature Review. J Breast Cancer. 2015;18(4):404-408.

Gallo M, Campione S, Di Vito V, Fortunati N, Lo Calzo F, Messina E, Ruggeri RM, Faggiano A, Colao AAL. Primary Neuroendocrine Neoplasms of the Breast: Still Open Issues. Front Endocrinology (Lausanne). 2021; 26;11: 610230.

Fujimoto Y, Yagyu R, Murase K, Kawajiri H, Ohtani H, Arimoto Y, Yamamura T, Inoue T, Moritani S. A case of solid neuroendocrine carcinoma of the breast in a 40-year-old woman. Breast Cancer. 2007;14(2):250-3.

Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biol Res. 2017; 2;50(1):33.

La Rosa S, Uccella S. Classification of neuroendocrine neoplasms: lights and shadows. Rev Endocr Metab Disord .2021; 22(3):527-538.

Trevisi E, La Salvia A, Daniele L, Brizzi MP, De Rosa G, Scagliotti GV, Di Maio M. Neuroendocrine breast carcinoma: a rare but challenging entity. Med Oncol. 2020;37(8):70.

Inno A, Bogina G, Turazza M, Bortesi L, Duranti S, Massocco A, Zamboni G, Carbognin G, Alongi F, Salgarello M, Gori S. Neuroendocrine Carcinoma of the Breast: Current Evidence and Future Perspectives. The Oncologist. 2016; 21(1):28-32.

Jeon CH, Kim SM, Jang M, Yun BL, Ahn HS, Kim SW, Kang E, Park SY. Clinical and radiologic features of neuroendocrine breast carcinomas. J Ultrasound Med. 2014;33(8):1511-1518.

Park YM, Wu Y, Wei W, Yang WT. Primary neuroendocrine carcinoma of the breast: clinical, imaging, and histologic features AJR Am J Roentgenol. 2014;203(2):W221-W230.

Rosen LE, Gattuso P. Neuroendocrine Tumors of the Breast. Arch Pathol Lab Med. 2017;141(11):1577-1581.

Canbak T, Acar A, Tolan HK, Ozbagriacik M, Ezberci F. Primary neuroendocrine carcinoma of the breast: a 5-year experiences. Ann Ital Chir. 2020;91:23-26.

Halbony, H., Salman, K., Alqassieh, A., Albrezat, M., Hamdan, A., Abualhaija'a, A., Alsaeidi, O., Masad Melhem, J., Sagiroglu, J, Alimoglu O. Breast cancer

epidemiology among surgically treated patients in Jordan: A retrospective study. Med J Islam Repub Iran. 2020;34:73.