@article{Yücel_İlanbey_2022, title={The relationship of Growth differentiation factor-15 with renal damage and dyslipidemia in non-albuminuric and albuminuric Type-2 Diabetes Mellitus}, volume={9}, url={https://medscidiscovery.com/index.php/msd/article/view/746}, DOI={10.36472/msd.v9i6.746}, abstractNote={<p><strong>Objective: </strong>Aim of this study is to investigate the correlation of Growth differentiation factor-15  with renal damage and dyslipidemia in Type-2 Diabetes Mellitus.</p> <p><strong>Material and Method:</strong> The study was conducted prospectively with patients diagnosed with Type-2 Diabetes Mellitus. Two groups were formed as non-albuminuric (n:47) and albuminuric (n:24). Age, gender, Growth differentiation factor-15, glycemic index, lipid panel, glomerular filtration rate, complete blood count, urine albumin/creatin and urine protein/creatin of the groups were compared, and their correlations were examined.</p> <p><strong>Results:</strong> Growth differentiation factor-15, age, and hemoglobin A1c were found to be higher in the albuminuric group, and hemoglobin and hematocrit levels were found to be lower. A positive correlation of Growth differentiation factor-15 with spot urine albumin/creatin and protein/creatin was observed in the albuminuric group. In the non-albuminuric group, positive correlation was observed with Triglyceride and a negative correlation with high-density lipoprotein cholesterol. Negative correlation of Growth differentiation factor-15 glomerular filtration rate was detected in all participants.</p> <p><strong>Conclusions: </strong>Growth differentiation factor-15 has been found positively associated with albuminuria and high triglyceride levels in Type-2 Diabetes Mellitus. It is negatively correlated with glomerular filtration rate and high-density lipoprotein cholesterol. It is strongly associated with renal damage and dyslipidemia.</p>}, number={6}, journal={Medical Science and Discovery}, author={Yücel, Hasan Esat and İlanbey, Bilal}, year={2022}, month={Jun.}, pages={334–339} }