TY - JOUR AU - Angın, Ali Doğukan AU - Sakin, Önder AU - Cıkman, Muzaffer Seyhan AU - Gün, İsmet AU - Denizli, Ramazan AU - Başak, Kayhan AU - Kaptanağası, Asuman Orçun AU - Alan, Yasemin AU - Alan, Murat PY - 2020/01/24 Y2 - 2024/03/29 TI - Protective effects of dehydroepiandrosterone (DHEA) vs caffeic acid phenethyl ester (CAPE) against ischemia-reperfusion injury in rat ovary: Dehydroepiandrosterone Caffeic Acid Phenethyl Ester Ischemia-Reperfusion JF - Medical Science and Discovery JA - Med Sci Discov VL - 7 IS - 1 SE - Research Article DO - 10.36472/msd.v7i1.347 UR - https://medscidiscovery.com/index.php/msd/article/view/347 SP - 384-389 AB - <p><strong>Objective:</strong> In this study, the effectiveness of caffeic acid phenethyl ester (CAPE) and Dehydroepiandrosterone (DHEA) in preventing ischemia reperfusion injury associated with ovarian torsion have been investigated.</p><p><strong>Materials and Methods:</strong> Twenty four adult female Wistar Albino rats were randomly divided into four groups. Ovaries were not twisted, and only healthy ovarian tissues were removed from the rats in the first group, while ovaries were twisted for 3 hours in the other groups. The second group did not receive any medications before the ovaries were untwisted, while 20 micromole/kg of CAPE was applied on peritoneal surface to the third group, and 60 mg/kg of DHEA was administered intraperitoneally to the fourth group.</p><p><strong>Results:</strong> The level of primordial follicles was higher in the third group compared to the second group after the torsion of the ovary (p=0.017). The mean level of primary follicles was higher in the first group compared to the number of follicles in the third and fourth groups after the torsion of the ovary (p&lt;0.001). The median hemorrhage level was higher in the second group following ovarian torsion compared to that in the first group (p=0.005).</p><p><strong>Conclusion:</strong> Agents that have been considered to reduce injury resulting from ischemia-reperfusion proved ineffective during the early stages in terms of the number of follicles in the ovaries; however, we believe that long-term studies may be more beneficial.</p> ER -