Mortality Attributed to Central and Peripheral Nervous System Disorders: A Five-years Comprehensive Review from Turkey Central and Peripheral Nervous System Related Mortalities

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Ceyda Hayretdağ


Objective: This study aims to provide a comprehensive overview of deaths related to central and peripheral nervous system (CNS and PNS, respectively) disorders in Turkey over a 5-year period. The objective is to identify patterns in mortality rates, investigate regional prevalence, and analyze demographic factors contributing to fatal outcomes. Additionally, we aim to critique existing data collection methodologies.

Materials and Methods: Utilizing cross-sectional analysis, data were obtained from the Turkish Statistical Institute (TUIK). Mortality rates were calculated using population estimates from the TUIK, with age- and sex-specific rates, and age-standardized rates (ASRs) derived from the world standard population. Causes of death were classified according to the World Health Organization's International Classification of Diseases, Tenth Revision (ICD-10).

Results: The data revealed distinct patterns in mortality rates for CNS and PNS disorders from 2018 to 2022, with significant variations between male and female populations. A prominent upward trend in deaths attributed to CNS and PNS diseases was observed after 2018, despite a decline in the population growth rate. The highest mortality rates were particularly notable in 2020 and 2021.

Conclusion: This study identified a significant increase in deaths related to CNS and PNS disorders amid the backdrop of the COVID-19 pandemic. A potential correlation between COVID-19 and the prevalence of neurological disorders has been suggested. With potential underdiagnosis due to the absence of routine post-mortem diagnostic autopsies, this study underscores the need for improved diagnostic capabilities and medical practices.


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How to Cite
Hayretdağ, C. (2023). Mortality Attributed to Central and Peripheral Nervous System Disorders: A Five-years Comprehensive Review from Turkey: Central and Peripheral Nervous System Related Mortalities. Medical Science and Discovery, 10(10), 901–906.
Research Article
Received 2023-10-23
Accepted 2023-10-29
Published 2023-10-30


ten Donkelaar HJ, Takakuwa T, Vasung L, Yamada S, Shiota K, van der Vliet T. Overview of the development of the human brain and spinal cord. Clinical neuroembryology: development and developmental disorders of the human central nervous system: Springer; 2023. p. 1-76. DOI:

Heimer L. The human brain and spinal cord: functional neuroanatomy and dissection guide: Springer Science & Business Media; 2012.

Aykaç S. A Decade Trends in Total and Sex-specific Cerebrovascular Disease Mortality in Turkey: 2013-2022: Cerebrovascular Mortality Trends in Turkey: 2013-2022. Medical Science and Discovery. 2023;10(10):792-6. DOI:

Guerrero JI, Barragán LA, Martínez JD, Montoya JP, Peña A, Sobrino FE, et al. Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings. BMC infectious diseases. 2021;21(1):1-15. DOI: CNS deaths.

SÖNMEZ FT, SÖNMEZ CI. Turkey and Europe data comparison in terms of the course of the COVID-19 pandemic and health expenses. Family Practice and Palliative Care. 2022;7(2):55-8. DOI:

Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS chemical neuroscience. 2020;11(7):995-8. DOI:

Munhoz RP, Pedroso JL, Nascimento FA, Almeida SMd, Barsottini OGP, Cardoso FEC, et al. Neurological complications in patients with SARS-CoV-2 infection: a systematic review. Arquivos de Neuro-Psiquiatria. 2020;78:290-300. DOI:

De Cock KM, Zielinski-Gutiérrez E, Lucas SB. Learning from the dead. The New England journal of medicine. 2019;381(20):1889-91. DOI:

Mao R, Liang J, Shen J, Ghosh S, Zhu L-R, Yang H, et al. Implications of COVID-19 for patients with pre-existing digestive diseases. The lancet Gastroenterology & hepatology. 2020;5(5):425-7. DOI:

Sriwijitalai W, Wiwanitkit V. COVID-19 in forensic medicine unit personnel: Observation from Thailand. Journal of forensic and legal medicine. 2020;72:101964. DOI:

Chen Y-Y, Assefa Y. The heterogeneity of the COVID-19 pandemic and national responses: an explanatory mixed-methods study. BMC Public Health. 2021;21(1):835. DOI:

Filip R, Gheorghita Puscaselu R, Anchidin-Norocel L, Dimian M, Savage WK. Global challenges to public health care systems during the COVID-19 pandemic: a review of pandemic measures and problems. Journal of Personalized Medicine. 2022;12(8):1295. DOI:

Bourbeau P, Marcoux J-M, Ackerly BA. A Multidisciplinary Approach to Pandemics: COVID-19 and Beyond: Oxford University Press; 2022. DOI:

Afshar H, Yassin Z, Kalantari S, Aloosh O, Lotfi T, Moghaddasi M, et al. Evolution and resolution of brain involvement associated with SARS-CoV2 infection: a close clinical–paraclinical follow up study of a case. Multiple sclerosis and related disorders. 2020;43:102216. DOI:

Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY, et al. Characteristics of ischaemic stroke associated with COVID-19. Journal of Neurology, Neurosurgery & Psychiatry. 2020;91(8):889-91. DOI:

Bernard-Valnet R, Pizzarotti B, Anichini A. Two patients with acute meningo-encephalitis concomitant to SARS-CoV-2 infection. medRxiv. 2020; 20060251. Publisher Full Text. DOI: