Do antiepileptic drugs have any effect on Neutrophil / Lymphocyte and Platelet / Lymphocyte Ratio?

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İlhan Çağ
Yaşar Altun
Erman Altunışık


Objective: The aim of this study was to compare the complete blood count values of 40 healthy individuals and 60 patients who are using antiepileptic drugs (AEDs), specifically to evaluate neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), and basophil-lymphocyte ratio (BLR). This study is important because it is the first study on hematological parameters such as NLR, MLO, PLO and BLO.

Material and Methods: In this study, hemogram and biochemical data of 17 patients who received carbamazepine (CBZ), 21 patients with valproic acid (VPA), 22 patients with levetiracetam (LEV) along with 40 healthy controls were gathered and compared. The differences between the groups were evaluated statistically.

Results: No difference was present between the groups in terms of age or gender (p> 0.05). NLR was 2.19±1.42 for patients using CBZ, 1.64±1.34 for VPA users, 2.18±0.73 for LEV users and 2.04±0.85 for control group (p> 0.05). NLR, MLR, PLR and BLR were not significantly different from the control group. 

Conclusion: To our knowledge, no study has targeted the haematological effects of antiepileptics on NLR, MLR, PLR and BLR. This study was important because it is the first study the effect of various antiepileptics on the hematological parameters such as NLR, MLR, PLR, and BLR. We believe that our study will articulate new studies.


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Çağ , İlhan ., Altun, Y. ., & Altunışık, E. . (2019). Do antiepileptic drugs have any effect on Neutrophil / Lymphocyte and Platelet / Lymphocyte Ratio?. Medical Science and Discovery, 6(4), 76–81. Retrieved from
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