A Comparison of vitamin D deficiency with neutrophil lymphocyte ratio and CRP levels in Covid-19 patients

Main Article Content

Aslıhan Dilara Demir
Zeynep Hulya Durmaz

Abstract

Objective: Objective: We aimed to evaluate the association of neutrophil-lymphocyte ratio (NLR) and C reactive protein (CRP), ferritin, sedimentation levels with vitamin D concentrations in Covid-19 patients and to investigate  their effect of  levels on Covid-19 patients.


Materials and Methods: Forty-six patients aged 18-85 were included in our study. Our study is a retrospective study. Patients were divided into 2 groups with the first group consisting of those with vitamin D level 20 and below and 2nd group consisting of those with vitamin D level above 20. After Vitamin D, CRP, neutrophil, and lymphocyte values were retrospectively investigated with the hospital database, vitamin D levels were compared to CRP and neutrophil/lymphocyte ratio. 


Results: A positive correlation between CRP and SED, CRP and ferritin, NLR, and ferritin was observed in Covid-19 positive patients with Vitamin D level > 20. A positive correlation between NLR and CRP was observed in Covid-19 positive patients with Vitamin D level ≤ 20.


Conclusion: In patients with Vitamin D levels >20, there was a significant correlation between vitamin D and NLR and a moderate correlation between Vitamin D and CRP. In patients with Vitamin D levels <20, there was a positive correlation of Vitamin D with CRP and NLR.

Downloads

Download data is not yet available.

Article Details

How to Cite
Demir, A. D., & Durmaz, Z. H. (2021). A Comparison of vitamin D deficiency with neutrophil lymphocyte ratio and CRP levels in Covid-19 patients. Medical Science and Discovery, 8(5), 306-309. https://doi.org/10.36472/msd.v8i5.537
Section
Research Article

References

1. Lu H.Drug treatment options for the 2019-new coronavirus. BioScience Trends. 2020; 14(1):69-71.DOI: 10.5582/bst.2020.01020

2. World Health Organization. Coronavirus disease 2019 (COVID-19): situation report, vol. 167 https://apps.who.int/iris/bitstream/handle/10665/333146/nCoVsitrep05Jul2020-eng.pdf?sequence=1&isAllowed=y Available 22.01.2021

3. Zhou P, Yang XL, Wang XG, Zhang L, Zhang W, Si HR et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798): 270–273.Published online 2020 Feb 3. doi: 10.1038/s41586-020-2012-7

4. Drosten C, Günther S. , Preiser W, Werf S., Brodt H., Becke. s Identification of a novel coronavirus in patients with severe acute respiratory syndrome N Engl J Med 2003 May 15;348(20):1967-76. doi: 10.1056/NEJMoa030747.

5. Ren L.L., Wang Y.M., Wu Z.Q Wu, Zhi-Qiang4; Xiang,et al. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chinese Medical Journal: May 5, 2020 - Volume 133 - Issue 9 - p 1015-1024doi: 10.1097/CM9.0000000000000722

6. Holick, M.F. Vitamin D deficiency N. N Engl J Med 2007; 357:266-281 DOI: 10.1056/NEJMra070553






7. Rondanelli, M.; Miccono, A.; Lamburghini, S. Avanzato I , Riva A 2, Allegrini Pet al. Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds Evid Based Complement Alternat Med 2018 Apr 29;2018:5813095.doi: 10.1155/2018/5813095. eCollection 2018.

8. Schwalfenberg, G.K A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol Nutr Food Res2011 Jan;55(1):96-108. doi: 10.1002/mnfr.201000174.

9. Marnell L. Mold C, Du Clos TW. C-reactive protein: ligands, receptors and role in inflammation. Clinical Immunology Volume 117, Issue 2, November 2005, Pages 104-111 https://doi.org/10.1016/j.clim.2005.08.004

10. Cannell JJ, Vieth R, Umhau JC, et al. Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition . Epidemiol Infect.134( 2006),pp.1129-40.

11. Glicio EJ. Vitamin D level of mild and severe elderly cases of COVID-19: a preliminary report

12. Raharusun P., Priambada S., Budiarti C.,. Agung E, Budi C et al.Patterns of COVID-19 mortality and vitamin D: an Indonesian study. SSRN J. (2020), pp1-14

13. Hastie C.E, Mackay D.F, Ho .F, Morales C.A.C Katikireddi V. S. Niedzwiedz C.L. et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes & Metabolic Syndrome: Clinical Research & Reviews.14 (2020) pp 561-565 https://doi.org/10.1016/j.dsx.2020.04.050

14. Sabetta J.R. Depetrillo P,Cipriani.R.J. Smardin J, Burns L.A, Landry ML et al. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 2010 Jun 14;5(6):e11088. doi: 10.1371/journal.pone.0011088.

15. Mardani R, Alamdary A, Nasab M.S, Gholami R. Ahmadi N. Gholami A. et al. Association of vitamin D with the modulation of the disease severity in COVID-19 Virus Research Volume 289, November 2020, 198148 https://doi.org/10.1016/j.virusres.2020.198148

16. Hastie. C, Mackay D.F, Ho F, Carlos A., Celis-Morales C.A., Katikireddi V.S., Claire L. Niedzwiedz C.L. et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr. 2020 Jul-Aug; 14(4): 561–565.doi: 10.1016/j.dsx.2020.04.050