Serum Levels of BDNF, TNF alpha, Caspaz-3, AChE, BChE in Patients with Brain Tumor

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Published: Feb 21, 2023
DOI: https://doi.org/10.36472/msd.v10i2.884
Keywords:
Acetylcholine Brain Tumor BDNF TNF-α Caspaz-3 AChE

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Abdurrahim Tas
Department of Neurosurgery, Medical School, Dicle University, Diyarbakir, TR
Abdurrahman Aycan
Department of Neurosurgery, Medical School, University of Van Yuzuncu Yıl, Van, TR
Gokhan Gurkan
Department of Neurosurgery, Katip Celebi University Atatürk Training and Research Hospital, Izmir, TR
Asli Cilingir Yeltekin
Department of Chemistry, Faculty of Science, University of Van Yuzuncu Yıl, Van, TR
Sama-Amer Abbas El-Tekreti
Department of Chemistry, Faculty of Science, University of Van Yuzuncu Yıl, Van, TR
Nur Aycan
Department of Pediatrics, Medical School, University of Van Yuzuncu Yıl, Van, TR

Abstract

Objective: Brain tumor development mechanisms are still the subject of current research, and treatment models are improving. Our study aimed to investigate the association of cytokines with intracranial tumor types and grades and their usability in diagnosis and follow-up.


Material and Methods: This study included 48 individuals (24 brain tumors and 24 control groups). The blood samples were taken from the study groups, and biochemical analysis was performed. The groups were then compared for statistical significance.


Results: In our study, our aim was to investigate the relationship between enzyme levels and intracranial tumors in various pathologies and grades. We found a significant association between TNF-α, Caspase-3, and BChE enzymes, but this association was not observed for BDNF and AChE.


Conclusion: We measured the levels of various cytokines secreted in gliomas and other brain tumors and carried out our study to determine whether these measurements cause changes in the staging of the disease, their use as a diagnosis, and the length of stay. This study would shed light on more comprehensive studies on brain tumors.

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How to Cite
Tas, A., Aycan, A., Gurkan, G., Cilingir Yeltekin, A., El-Tekreti, S.-A. A. ., & Aycan, N. (2023). Serum Levels of BDNF, TNF alpha, Caspaz-3, AChE, BChE in Patients with Brain Tumor. Medical Science and Discovery, 10(2), 109–113. https://doi.org/10.36472/msd.v10i2.884
Issue
Vol. 10 No. 2 (2023): Medical Science and Discovery
Section
Research Article
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

https://creativecommons.org/licenses/by-nc/4.0/

Received 2023-02-13
Accepted 2023-02-19
Published 2023-02-21

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