Main Article Content
Objective: The evaluation of choroidal thickness measurements became possible after the developments in optical coherence tomography (OCT) technology. This study aimed to evaluate choroidal features in Retinitis Pigmentosa subjects with EDI (Enhanced depth imaging) mode spectral domain optical coherence tomography (SD-OCT).
Material and Method: A hundred and three eyes of 54 RP subjects underwent scanning with EDI-OCT for central retinal and choroidal thickness measurements and were compared with 40 healthy controls. Submacular choroidal thickness measurements were obtained beneath the fovea and at 500 µm intervals for 2.5 mm nasal and temporal to the center of the fovea.
Results: Mean subfoveal choroidal thickness measurements were 253.2±74.9 µm in RP patients and 336.2±91.7 µm in control (p<0.0001). There was no correlation between subfoveal choroidal thickness and visual acuity in RP patients. The choroid had an irregular shape in 85 % of RP patients. The thickest point of the choroid was not subfoveal as in healthy eyes, and excessive nasal thinning of the choroid was observed in 93 % of RP patients.
Conclusion: Submacular choroidal thickness was significantly reduced but did not correlate with the visual acuity in RP patients.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Hamel C. Retinitis pigmentosa. Orphanet journal of rare diseases. 2006;1(1):1-12.
DeBenedictis MJ, Rachitskaya A. 36 Retinitis Pigmentosa. The Retina Illustrated. 2019:16.
Dhoot DS, Huo S, Yuan A, Xu D, Srivistava S, Ehlers JP, et al. Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography. British Journal of Ophthalmology. 2013;97(1):66-9.
Lundberg K, Vergmann AS, Vestergaard AH, Jacobsen N, Goldschmidt E, Peto T, et al. A comparison of two methods to measure choroidal thickness by enhanced depth imaging optical coherence tomography. Acta Ophthalmol. 2019;97(1):118-20.
Sodi A, Lenzetti C, Murro V, Caporossi O, Mucciolo DP, Bacherini D, et al. EDI-OCT evaluation of choroidal thickness in retinitis pigmentosa. European Journal of Ophthalmology. 2018;28(1):52-7.
Salafian B, Kafieh R, Rashno A, Pourazizi M, Sadri S. Automatic segmentation of choroid layer in edi oct images using graph theory in neutrosophic space. arXiv preprint arXiv:181201989. 2018.
Lin E, Ke M, Tan B, Yao X, Wong D, Ong L, et al. Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study. Scientific reports. 2020;10(1):1-9.
Ueda‐Consolvo T, Fuchizawa C, Otsuka M, Nakagawa T, Hayashi A. Analysis of retinal vessels in eyes with retinitis pigmentosa by retinal oximeter. Acta Ophthalmologica. 2015;93(6):e446-e50.
Sodi A, Mucciolo DP, Murro V, Zoppetti C, Terzuoli B, Mecocci A, et al. Computer-assisted evaluation of retinal vessel diameter in retinitis pigmentosa. Ophthalmic Research. 2016;56(3):139-44.
Yu D-Y, Cringle SJ, Su E-N, Paula KY. Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat. Investigative ophthalmology & visual science. 2000;41(12):3999-4006.
Ikeda Y, Yoshida N, Murakami Y, Notomi S, Hisatomi T, Enaida H, et al. Sustained Chronic Inflammatory Reaction In Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science. 2012;53(14):4563-.
Viringipurampeer IA, Bashar AE, Gregory-Evans CY, Moritz OL, Gregory-Evans K. Targeting inflammation in emerging therapies for genetic retinal disease. International Journal of Inflammation. 2013;2013.
Yoon CK, Yu HG. The structure-function relationship between macular morphology and visual function analyzed by optical coherence tomography in retinitis pigmentosa. Journal of Ophthalmology. 2013;2013.
Yeoh J, Rahman W, Chen F, Hooper C, Patel P, Tufail A, et al. Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography. Graefe's Archive for Clinical and Experimental Ophthalmology. 2010;248(12):1719-28.
Battaglia Parodi M, La Spina C, Triolo G, Riccieri F, Pierro L, Gagliardi M, et al. Correlation of SD-OCT findings and visual function in patients with retinitis pigmentosa. Graefe's Archive for Clinical and Experimental Ophthalmology. 2016;254(7):1275-9.
Tuncer I, Karahan E, Zengin MO, Atalay E, Polat N. Choroidal thickness in relation to sex, age, refractive error, and axial length in healthy Turkish subjects. International Ophthalmology. 2015;35(3):403-10.
Ayton LN, Blamey PJ, Guymer RH, Luu CD, Nayagam DA, Sinclair NC, et al. First-in-human trial of a novel suprachoroidal retinal prosthesis. PloS one. 2014;9(12):e115239.
Ayton LN, Guymer RH, Luu CD. Choroidal thickness profiles in retinitis pigmentosa. Clinical & experimental ophthalmology. 2013;41(4):396-403.
Adhi M, Duker JS. Optical coherence tomography–current and future applications. Current opinion in ophthalmology. 2013;24(3):213.
Boonarpha N, Zheng Y, Stangos AN, Lu H, Raj A, Czanner G, et al. Standardization of choroidal thickness measurements using enhanced depth imaging optical coherence tomography. International journal of ophthalmology. 2015;8(3):484.