Prognostic Factors Affecting Local Recurrence and Systemic Metastasis in Early Stage Breast Cancer

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Zafer Pekkolay
Abdurrahman Işıkdoğan


Objective: Breast cancer is the most common cancer in women. Mortality in breast cancer is associated with recurrence and metastases. The aim of this study was to determine the causes of local recurrence and metastasis in operated early stage breast cancer.

Material and Methods: The files of the patients diagnosed with operated early stage breast cancer followed up at Dicle University Medical Faculty Medical Oncology Department between 2001-2010 were analyzed retrospectively. The group of patients with recurrence was referred to as the relapse-metastasis group and the other patients were called the remission group. Between these two groups, age, sex, tumor histology, size, presence of lymphovascular invasion, tumor grade molecular properties such as, ER, PR, HER, staging studies; time characteristics, surgical characteristics, time between surgery-chemotherapy and surgery-radiotherapy; The relapse-metastasis group and the remission group were compared in terms of chemotherapy. SPSS 22 was used for statistical analysis. p<0.05 was considered significant.

Results: 479 patients were included in the study. The number of patients in the remission and relapse-metastasis group was 343 and 136, respectively. Tumor diameter was 3.33 cm in the remission group and 4.58 cm in the relapse-metastasis group, and the difference was statistically significant (p<0.01). The percentage of involvement of more than 4 lymph nodes were 30.45% and 55.7% in the remission and relapse-metastasis groups, respectively (p <0.01). The percentage of the lymphovascular invasions were remission group and relapse-metastasis group 46.4% and 80% respectively. The percentage of patients with surgery-chemotherapy time> 1 month was 9.7% and 24% in the remission and relapse-metastasis group, respectively. In remission group 30.9%; relapse-metastasis group 47.7% of the patients had incomplete staging at the time of diagnosis.

Conclusion: The factors determining the recurrence in patients with operated early stage breast cancer were tumor size, number of lymph node involvement, incomplete staging at the time of diagnosis, start chemotherapy later than 1 month.


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Pekkolay, Z., & Işıkdoğan, A. (2019). Prognostic Factors Affecting Local Recurrence and Systemic Metastasis in Early Stage Breast Cancer. Medical Science and Discovery, 6(7), 119-122. Retrieved from
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