Treatment of Chorioamnionitis with Piperacillin/Tazobactam and Clindamycin

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Metin Kaba


Objective: Chorioamnionitis is a condition that bacteria infects the chorion and amnion and the amniotic fluid which can affect pregnant women. Infections may affect both the mother and fetus. Cervical insufficiency and chorioamnionitis cause preterm birth and perinatal morbidities.

Case: A 37-year-old patient was referred to the clinic with the diagnosis of preterm labor and cervical insufficiency at 26 weeks + 4 days of pregnancy. Cervix was 3 cm dilated, effaced 70%, the amnion membrane intact, and there was a cerclage thread on the cervix. There was a single, viable fetus in the uterine cavity with fetal measurements compatible with 27-28 weeks on ultrasonography. Ampicillin and azithromycin treatments were started. On the seventh day of observation, leukocytes and C reactive protein values had increased, and there was an onset of serohemorrhagic vaginal discharge. Thereupon, intravenous treatment of piperacillin/tazobactam and clindamycin started. Signs of chorioamnionitis were resolved. The patient was delivered on day 38 of admission due to vaginal bleeding. The newborn and patient outcomes were good. Further studies are needed to evaluate the new treatment regime's efficacy in chorioamnionitis treatment.


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How to Cite
Kaba, M. (2022). Treatment of Chorioamnionitis with Piperacillin/Tazobactam and Clindamycin. Medical Science and Discovery, 9(6), 368–370.
Case Reports
Received 2022-05-02
Accepted 2022-06-08
Published 2022-06-29


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