Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert's Syndrome

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Published: Jul 27, 2019
Keywords:
NonHDLc/HDLc ratio Gilbert's syndrome(GS) Unconjugated hyperbilirubinemia (UB) Non-HDL-cholesterol HDL cholesterol

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Salim Ozenc
Dept. of Family Medicine, Diyarbakır Military hospital, Diyarbakır Turkey
Hakan Sarlak
Dept. of Internal Medicine, Diyarbakır Military hospital, Diyarbakır Turkey
Sinan Iscen
Dept. of Cardiology, Diyarbakır Military hospital, Diyarbakır Turkey

Abstract

Objective: We investigated the relationship between HDL-cholesterol levels that is indirect marker of ApoA-I production in liver, Non-HDL-cholesterol that is indirect marker of ApoB and GS


Methods: HDLc, NonHDLc/ HDLc Ratio levels were investigated in subjects with GS (n=148) and compared to healthy controls (n=148).


Results: Age and BMI distributions were similar between the two groups. HDLc levels were lower in GS than the healthy controls (p=0.012). However, TC, Non-HDLc, Non-HDLc/HDLc levels were higher in GS than the healthy controls (p=0.002, p=0.001, p<0.001, respectively). In correlation analysis, UB were negatively mildly correlated with HDLc (r=−0.191, p=0.001) and positively correlated with TC (r=0.436, p<0.001), Non-HDLc (r=0.511, p<0.001) and Non-HDLc/HDLc (r=0.512, p<0.001) in the whole group.


Conclusions: The contrary of previously studies, we would like to suggest that bilirubin is a only antioxidant agent that protects from cardiovascular disease, but not physiological hypolipidemic agent.

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How to Cite
Ozenc, S. ., Sarlak, H. ., & Iscen, S. . (2019). Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome. Medical Science and Discovery, 2(6), 334–338. Retrieved from https://medscidiscovery.com/index.php/msd/article/view/78
Issue
Vol. 2 No. 6 (2015): Medical Science and Discovery
Section
Research Article

https://creativecommons.org/licenses/by-nc/4.0/

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