Relationship Between Premature ventricular complexes and Neutrophil–Lymphocyte Ratio in asymptomatic healty young men
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Abstract
Background: Premature ventricular complexes (PVC) are a relatively common electrocardiographic abnormality presenting in individuals without overt cardiovascular disease. There is no clear mortality benefit from VPB suppression in asymptomatic patients. In addition, It has been showed that evidence for structural heart disease consistent with non-ischemic scarring possibly due to inflammation in patients with premature ventricular beats . This situation suggests that the mechanisms by which VPBs can be also generated with include clinical and subclinical inflammation. The neutrophil–lymphocyte ratio (NLR) is an easy, cheap, noninvasive, and universally available laboratory marker used to evaluate clinical and subclinical systemic inflammation.We investigated the NLR in asymptomatic healty young men with PVC(structural heart disease excluded with cardiac magnetic resonance imaging) compared with controls.
Methods: The study group consisted of 21 asymptomatic(or atypical complaint) healty young men with PVC ( mean age 22.7 ± 2.0 years.
Results:There were no significant differences between the 2 groups with respect to age, gender, body mass index, smoking, as well as glucose, creatinine, total cholesterol, triglyceride, LDL-C, HDL-C, hemoglobin levels, white blood cell count, and red cell distribution width. The NLR was significantly higher among the men with PVC than that of the control group (2.7 ±0.7 vs 1.5 ± 0.4, respectively; P < .001).
Conclusions: We found that the NLR is significantly elevated in asymptomatic healty young men with PVC compared with control participants. The increased NLR values might indicate subclinical and clinical inflammation in asymptomatic healty young men with PVC ,and we must consider that there
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Kennedy HL, Whitlock JA, Sprague MK, Kennedy LJ, Buckingham TA,Goldberg RJ et al. Long-term follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. N Engl J Med 1985; 12:193-197.
Gaita F, Giustetto C, Di Donna P, Richiardi E, Libero L, Rosa MC et al. Long-term follow-up of right ventricular monomorphic extrasystoles. J Am Coll Cardiol 2001; 38:364-370.
Sajadieh A, Nielsen OW, Rasmussen V, Hein HO, Frederiksen BS, Davanlou M et al.Ventricular arrhythmias and risk of death and acute myocardial infarction in apparently healthy subjects of age. Am J Cardiol 2006; 97:1351-57.
Cheriyath P, He F, Peters I, Li XA, Alagona P, Wu CT et al. Relation of atrial and/or ventricular premature complexes on a two-minute rhythm strip to the risk of sudden cardiac death (the atherosclerosis risk in communities [ARIC] study. Am J Cardiol 2011; 107:151-55.
Stein PK, Sanghavi D, Sotoodehnia N, Siscovick DS, Gottdiener J. Association of Holter-based measures including T-wave altemans with risk of sudden cardiac death in the community-dwelling elderly: the cardiovascular health study. J Electrocardiol 2010; 43:251-59.
Abdalla ISH, Prineas RJ, Neaton JD, Jacobs DR et al.Relation between ventricular premature complexes and sudden cardiac death in apparently healthy men. Am J Cardiol 1987; 60:1036-42.
Raiha IJ, Piha SJ, Seppanen A, Puukka P, Sourander L. Predictive value of continuous ambulatory electrocardiographic monitoring in elderly people. Br Med J 1994; 309:1263-67.
Jeserich M, Friedrich MG, Olschewski M, Kirchberger J, Kimmel S, Bode C et al. Evidence for non-ischemic scarring in patients with ventricular ectopy. Int J Cardiol. 2011;147:482-84.
Arbel Y, Finkelstein A, Halkin A, Birati EY, Revivo M, Zuzut M et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography Atherosclerosis. 2012;225:456-60.
Kaya MG. Inflammation and coronary artery disease: as a new biomarker neutrophil/lymphocyte ratio [in Turkish]. Turk Kardiyol Dern Ars. 2013;41(3):191-192.
Kaya MG, Akpek M, Lam YY, Yarlioglues M, Celik T, Gunebakmaz O, et al.Prognostic value of neutrophil/ lymphocyte ratio in patients with ST-elevated myocardial infarction undergoing primary coronary intervention: a prospective, multicenter study. Int J Cardiol.2013 168(2):1154-9
Kalay N, Dogdu O, Koc F, Yarlioglues M, Ardic I, Akpek M, et al. Hematologic parameters and angiographic progression of coronary atherosclerosis. Angiology. 2012; 63(3):213-217.
Stein PK, Barzilay JI, Chaves PHM, Mistretta SQ, Domitrovich PP, Gottdiener JS, et al. Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the cardiovascular health study (CHS). J Cardio Electrophysiol 2008, 19:1169-74.
Balta S, Demirkol S, Cakar M, Arslan Z, Unlu M, Celik T. Other inflammatory markers should not be forgotten when assessing the neutrophil-to-lymphocyte ratio [published online April 23]. Clin Appl Thromb Hemost. 2013.19(6):693-4.
Sahin DY, Elbasan Z, Gür M, Yildiz A, Akpinar O, Icen YK, et al. Neutrophil to lymphocyte ratio is associated with the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction. Angiology. 2012. 64(6):423-9