Some mineral, trace element and heavy metal concentrations in newborns with esophageal atresia and their mothers

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Mehmet Melek
Halit Demir
Fatih Caglar Celikezen
Nesrin Ceylan
Salim Bilici
Kemal Agengin
Ismet Alkis
Ufuk Cobanoglu
Tugba Gur
Canan Demir
Nihat Demir


Objective: The aim was to reveal some minerals, trace elements and heavy metal levels in newborns with esophageal atresia (EA) and their mothers and determine whether there is a relationship between these values and this disease.

Material and Methods: The study included a total of 60 subjects (15 newborns with EA, 15 healthy newborns and their mothers). Blood samples of each subject were obtained. Serum concentrations of copper (Cu), zinc (Zn), magnesium (Mg), manganese (Mn), lead (Pb), cadmium (Cd), and iron (Fe) were determined.

Results: Serum Mg, Mn, Zn, Cd, Cu levels were significantly higher in newborns with EA compared to healthy newborns (p<0.01). Pb level was significantly lower in newborns with EA than those of control group (p<0.01). Serum Cd levels were significantly lower in the mothers of newborns with of healthy newborns. The effect on the infants with EA with higher level of heavy metals was more significant. These changes were limited in their mothers.

Conclusion: These findings may suggest that minerals and heavy metals with the pathogenesis of this disease might interact in the biomolecular level.


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Melek, M. ., Demir, H. ., Celikezen, F. C. ., Ceylan, N. ., Bilici, S. ., Agengin, K. ., Alkis, I. ., Cobanoglu, U. ., Gur, T. ., Demir, C. ., & Demir, N. . (2019). Some mineral, trace element and heavy metal concentrations in newborns with esophageal atresia and their mothers. Medical Science and Discovery, 1(4), 109–114. Retrieved from
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