Exploring the Impact of Trace Elements and Heavy Metals on Colon Cancer

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Seerwan Hamadameen Sulaiman
Halit Demir


Objective: The complex disease of colon cancer is impacted by a number of genetic, dietary, and environmental variables. This article investigates the role of heavy metals and trace elements in colon cancer growth pathways. The critical role that trace elements play in numerous physiological processes is the main reason that their presence has such a significant impact on how the body functions.

Material and Methods: In a cross-sectional investigation that was conducted from August 2022 to January 2023, zinc (Zn), manganese (Mn), calcium (Ca) , chromium (Cr), copper (Cu), lead (Pb), sodium (Na), magnesium (Mg), selenium (Se), mercury (Hg),potassium (K), and iron (Fe) levels were measured in CRC cases.

Results: The average age of the people in the study group was 77.4 ± 28.1. The median level of K, Hg, Cu, and Fe in cancerous tissues was significantly increased than that of healthy tissues (P <0.05). Still, the median of Zn, Cr, Mn, Pb, Na, Se, and Ca was much lower in cancerous tissues (P <0.05) than in non-cancerous tissues.

Conclusion: We found that the amount of some trace elements may depend on the person's gender and how long they have smoked. We found that the amounts of eight elements were much different in cancerous tissues than in healthy ones.


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Sulaiman, S. H. ., & Demir, H. (2023). Exploring the Impact of Trace Elements and Heavy Metals on Colon Cancer. Medical Science and Discovery, 10(10), 736–743. https://doi.org/10.36472/msd.v10i10.1037 (Original work published October 3, 2023)
Research Article
Received 2023-09-02
Accepted 2023-09-12
Published 2023-10-11


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