Some mineral, trace element and heavy metal concentrations in newborns with esophageal atresia and their mothers
Main Article Content
Objective: The aim was to reveal some minerals, trace elements and heavy metal levels in newborns with esophageal atresia (EA) and their mothers and determine whether there is a relationship between these values and this disease.
Material and Methods: The study included a total of 60 subjects (15 newborns with EA, 15 healthy newborns and their mothers). Blood samples of each subject were obtained. Serum concentrations of copper (Cu), zinc (Zn), magnesium (Mg), manganese (Mn), lead (Pb), cadmium (Cd), and iron (Fe) were determined.
Results: Serum Mg, Mn, Zn, Cd, Cu levels were significantly higher in newborns with EA compared to healthy newborns (p<0.01). Pb level was significantly lower in newborns with EA than those of control group (p<0.01). Serum Cd levels were significantly lower in the mothers of newborns with of healthy newborns. The effect on the infants with EA with higher level of heavy metals was more significant. These changes were limited in their mothers.
Conclusion: These findings may suggest that minerals and heavy metals with the pathogenesis of this disease might interact in the biomolecular level.
Goyal A, Jones MO, Couriel JM, Losty PD. Oesophageal atresia and tracheo-oesophageal fistula. Archives of disease in childhood Fetal and neonatal edition. 2006;91(5):F381-4.
Orenstein S, Peters J, Khan S. The digestive system. congenital anomalies: esophageal atresia and trachesophageal fistula. In Behrman RE, Kliegman RM, Jenson HB (eds.). Nelson textbook of pediatrics. Philadelphia, PA: WB Saunders. 2003;1219-1222.
Holder TM, Ashcraft KW, Sharp RJ, Amoury RA. Care of infants with esophageal atresia, tracheoesophageal fistula, and associated anomalies. The Journal of thoracic and cardiovascular surgery. 1987;94(6):828-35.
Coran AG, Adzick NS, Krummel TM, Laberge JM, Shamberger RC, Caldamone AA. Pediatric Surgery. 7th ed. Saunders, Philadelphia. 2012.
Melek M, Demir H, Bilici S, Beger B, Cobanoglu U, Meral I, et al. Oxidative stress and antioxidant enzyme activities in newborns with oesophageal atresia and their mothers. The Journal of international medical research. 2012;40(1):249-57.
Demir H, Kanter M, Coskun O, Uz YH, Koc A, Yildiz A. Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic beta-cell damage in cadmium-treated rats. Biological trace element research. 2006;110(2):151-62.
Sarkar S, Yadav P, Trivedi R, Bansal AK, Bhatnagar D. Cadmium-induced lipid peroxidation and the status of the antioxidant system in rat tissues. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements. 1995;9(3):144-9.
Simpkins C, Lloyd T, Li S, Balderman S. Metallothionein-induced increase in mitochondrial inner membrane permeability. The Journal of surgical research. 1998;75(1):30-4.
Kanabrocki EL, Case LF, Fields T, Graham L, Miller EB, Oester YT, et al. Manganese and copper levels in human urine. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1965;6(11):780-91.
Lustberg M, Silbergeld E. Blood lead levels and mortality. Archives of internal medicine. 2002;162(21):2443-9.
Messner B, Knoflach M, Seubert A, Ritsch A, Pfaller K, Henderson B, et al. Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(9):1392-8.
Bilici M, Atasoy N, Kavak S, Demir H. Examining the level of some elements (Zinc, Chromium, Lead and Cadmium) and some liver enzymes (lower and upper) in the blood-serum of the workers at the car-reparing shops in the vicinity of Van. Fresenius Environ. Bull. 2012;4:904-905.
Gibson RS, Hess SY, Hotz C, Brown KH. Indicators of zinc status at the population level: a review of the evidence. The British journal of nutrition. 2008;99 Suppl 3:S14-23.
Heyland DK, Jones N, Cvijanovich NZ, Wong H. Zinc supplementation in critically ill patients: a key pharmaconutrient? JPEN Journal of parenteral and enteral nutrition. 2008;32(5):509-19.
Stamoulis I, Kouraklis G, Theocharis S. Zinc and the liver: an active interaction. Digestive diseases and sciences. 2007;52(7):1595-612.
Fischer Walker CL, Black RE. Functional indicators for assessing zinc deficiency. Food and nutrition bulletin. 2007;28(3 Suppl):S454-79.
Ramakrishnan U, Nguyen P, Martorell R. Effects of micronutrients on growth of children under 5 y of age: meta-analyses of single and multiple nutrient interventions. The American journal of clinical nutrition. 2009;89(1):191-203.
Andersen HS, Gambling L, Holtrop G, McArdle HJ. Effect of dietary copper deficiency on iron metabolism in the pregnant rat. The British journal of nutrition. 2007;97(2):239-46.
Carson BL, Ellis HV, Mc Cann JL, Antimony. In: Toxicology and Biological Monitoring of Metals in Humans. Chelsea, MI: Lewis. 1986;21-26.
Ilhan N, Ilhan N, Simsek M. The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia. Clinical biochemistry. 2002;35(5):393-7.
Paternain JL, Domingo JL, Corbella J. Developmental toxicity of cobalt in the rat. Journal of toxicology and environmental health. 1988;24(2):193-200.
Pedigo NG, George WJ, Anderson MB. Effects of acute and chronic exposure to cobalt on male reproduction in mice. Reproductive toxicology. 1988;2(1):45-53.
Alkıs I, Kavak S, Meral I, Oto G, Demir H. The effect of drospirenone/estradiol (angeliq®) on catalase and carbonic anhydrase enzyme activities with some biochemical element concentrations in ovariectomized rat model. Fresenius Environ. Bull. 2011;10:2543-2545.
Rahnama M, Marciniak A. Influence of estrogen deficiency on the level of magnesium in rat mandible and teeth. Bull. Vet. Inst. Pulawy. 2002;46:267-271.
Collery P, Anghileri LJ, Coudoux P, Durlach J. Magnesium and cancer: clinical data. Magnesium Bull. 1981;3:11-20.
Cobanoglu U, Demir H, Sayir F, Duran M, Mergan D. Some mineral, trace element and heavy metal concentrations in lung cancer. Asian Pacific journal of cancer prevention : APJCP. 2010;11(5):1383-8.
Arslan M, Demir H, Arslan H, Gokalp AS, Demir C. Trace elements, heavy metals and other biochemical parameters in malignant glioma patients. Asian Pacific journal of cancer prevention : APJCP. 2011;12(2):447-51.
Casanueva E, Viteri FE. Iron and oxidative stress in pregnancy. The Journal of nutrition. 2003;133(5 Suppl 2):1700S-8S.
Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutation research. 2001;475(1-2):7-20.